2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. Mutant IDH1 inhibitor

Mutant IDH1 inhibitor 

目录号: HY-13972 纯度: 99.40%
COA 产品使用指南

摩尔计算器

Mutant IDH1 inhibitor 是一个有效的突变型 IDH1 R132H 的抑制剂，IC50 值小于 72 nM。

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Mutant IDH1 inhibitor Chemical Structure

Mutant IDH1 inhibitor Chemical Structure

CAS No. : 1429180-08-4

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1642
In-stock
1 mg ￥680
In-stock
5 mg ￥1600
In-stock
10 mg ￥2800
In-stock
50 mg ￥6700
In-stock
100 mg ￥9100
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Mutant IDH1 inhibitor 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

WB

    Mutant IDH1 inhibitor purchased from MCE. Usage Cited in: Sci Rep. 2017 Oct 6;7(1):12758.  [Abstract]

    Represented western blot of an isothermal dose-response at melting temperature of 59°C demonstrating cellular mIDH1 enzyme thermal stabilization with mIDH1 inhibitors.

    查看 Isocitrate Dehydrogenase (IDH) 亚型特异性产品:

    查看所有亚型
    IDH1 IDH2

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.

    IC50 & Target

    IC50: < 72 nM (mutant IDH1 R132H)
    体外研究
    (In Vitro)

    Mutant IDH1 inhibitor is a potent IDH1 R132H inhibitor, and used for the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Mutant IDH1 inhibitor 相关抗体:
    分子量

    466.58

    Formula

    C25H34N6O3
    CAS 号
    性状

    固体

    颜色

    White to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : ≥ 34 mg/mL (72.87 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    * "≥" means soluble, but saturation unknown.

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.1433 mL 10.7163 mL 21.4326 mL
    5 mM 0.4287 mL 2.1433 mL 4.2865 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献
    Cell Assay
    [1]

    Day 1: cells are seeded in 384-well plates in triplicates for both the cell proliferation and 2HG assay, and incubated at 37°C, 95% Rh, 5% CO2 overnight. Day 2: compounds are serially diluted 1 :3 (10 point dilution from 10 mM solutions in DMSO) and delivered to the cell assay plates via acoustic dispenser, with final concentration ranging from 30 μM to 1.5 nM. The plates are returned to the incubator after treatment and incubated for 48 hours. Day 4 Proliferation assay: CTG is added to the assay plates and luminescence signal is read on the plate reader. Day 4 2HG assay : Extraction sample preparation consisted of aspirating all media from the assay plates, adding 70 μL of 90% methanol in water, dry ice incubation for 15 minutes, centrifuging at 2000 rpm for 30 min to ensure all particulates have settled, and transferring 30 μL of the supernatant into LC-MS ready plates. LC-MS analysis follows.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Mutant IDH1 inhibitor 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1433 mL 10.7163 mL 21.4326 mL 53.5814 mL
    5 mM 0.4287 mL 2.1433 mL 4.2865 mL 10.7163 mL
    10 mM 0.2143 mL 1.0716 mL 2.1433 mL 5.3581 mL
    15 mM 0.1429 mL 0.7144 mL 1.4288 mL 3.5721 mL
    20 mM 0.1072 mL 0.5358 mL 1.0716 mL 2.6791 mL
    25 mM 0.0857 mL 0.4287 mL 0.8573 mL 2.1433 mL
    30 mM 0.0714 mL 0.3572 mL 0.7144 mL 1.7860 mL
    40 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3395 mL
    50 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0716 mL
    60 mM 0.0357 mL 0.1786 mL 0.3572 mL 0.8930 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Mutant IDH1 inhibitor1429180-08-4Isocitrate Dehydrogenase (IDH)Inhibitorinhibitorinhibit

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    目录号：
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