1. Stem Cell/Wnt
  2. PKG
  3. PKG drug G1

PKG drug G1 靶向作用于 PKG Iα。PKG drug G1 通过 C42 PKGIα 非依赖性机制有助于血管舒张和血压降低。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PKG drug G1 Chemical Structure

PKG drug G1 Chemical Structure

CAS No. : 374703-78-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1076
In-stock
1 mg ¥380
In-stock
5 mg ¥1000
In-stock
10 mg ¥1500
In-stock
25 mg ¥2500
In-stock
50 mg ¥4500
In-stock
100 mg ¥7500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

IC50 & Target

PKG Iα[1]

体内研究
(In Vivo)

PKG drug G1 induces vasodilation of isolated resistance blood vessels and blood pressure lowering in a mouse model of angiotensin II–induced hypertension. PKG drug G1 efficiently relaxes WT but not knockin (KI) vessels, which is then assessed in a murine model of hypertension. PKG drug G1 lowers blood pressure in hypertensive WT, but not KI, mice in vivo. PKG drug G1 is tested in vivo in healthy mice implanted with telemetric devices that allow blood pressure and heart rate to be constantly monitored. PKG drug G1 or vehicle control is administrated by intraperitoneal injection, and the acute impact on hemodynamics assessed. PKG drug G1 administered at 7.4 mg/kg does not decrease blood pressure, but there is a concomitant reflex tachycardia. When this is repeated using 14.8 mg/kg dose of PKG drug G1, again blood pressure is not altered-but this higher dose induces a potentiated increase in heart rate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

257.31

Formula

C13H11N3OS

CAS 号
性状

固体

颜色

Light brown to reddish brown

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 75 mg/mL (291.48 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8864 mL 19.4318 mL 38.8636 mL
5 mM 0.7773 mL 3.8864 mL 7.7727 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
Mice constitutively expressing PKG Iα Cys42Ser are generated on a pure C57BL/6 background. Age-matched and body weight–matched WT or PKG Iα Cys42Ser KI male mice are used in all studies. Blood pressure and heart rate are assessed by radio telemetry in conscious freely moving mice. Alzet osmotic mini-pumps are used to deliver angiotensin II at 1.1 mg/kg per day in some studies. PKG drug G1 is delivered intraperitoneally (3.7-14.8 mg/kg) or orally (20 mg/kg) in some studies. To deliver PKG drug G1 orally, without stress or risk of dislodging the telemetric probe catheter, it is provided suspended in water and set in gelatin flavored with sodium saccharin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

PKG drug G1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8864 mL 19.4318 mL 38.8636 mL 97.1591 mL
5 mM 0.7773 mL 3.8864 mL 7.7727 mL 19.4318 mL
10 mM 0.3886 mL 1.9432 mL 3.8864 mL 9.7159 mL
15 mM 0.2591 mL 1.2955 mL 2.5909 mL 6.4773 mL
20 mM 0.1943 mL 0.9716 mL 1.9432 mL 4.8580 mL
25 mM 0.1555 mL 0.7773 mL 1.5545 mL 3.8864 mL
30 mM 0.1295 mL 0.6477 mL 1.2955 mL 3.2386 mL
40 mM 0.0972 mL 0.4858 mL 0.9716 mL 2.4290 mL
50 mM 0.0777 mL 0.3886 mL 0.7773 mL 1.9432 mL
60 mM 0.0648 mL 0.3239 mL 0.6477 mL 1.6193 mL
80 mM 0.0486 mL 0.2429 mL 0.4858 mL 1.2145 mL
100 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.9716 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
PKG drug G1
目录号:
HY-112197
需求量: