2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Pivalopril

Pivalopril  (Synonyms: 匹伏普利; Pivopril; RHC 3659(S))

目录号: HY-U00041 纯度: 99.19%
COA 产品使用指南

摩尔计算器

Pivalopril 是一种新的口服活性的血管紧张素转换酶 (ACE) 抑制剂。

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Pivalopril Chemical Structure

Pivalopril Chemical Structure

CAS No. : 81045-50-3

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规格 价格 是否有货 数量
1 mg ￥2040
In-stock
5 mg ￥5100
In-stock
10 mg ￥8200
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Pivalopril 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.

IC50 & Target

ACE[1]
体内研究
(In Vivo)

Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

329.45

Formula

C16H27NO4S
CAS 号
性状

固体

颜色

White to off-white

中文名称

匹伏普利
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 90 mg/mL (273.18 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0354 mL 15.1768 mL 30.3536 mL
5 mM 0.6071 mL 3.0354 mL 6.0707 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Pivalopril 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0354 mL 15.1768 mL 30.3536 mL 75.8840 mL
5 mM 0.6071 mL 3.0354 mL 6.0707 mL 15.1768 mL
10 mM 0.3035 mL 1.5177 mL 3.0354 mL 7.5884 mL
15 mM 0.2024 mL 1.0118 mL 2.0236 mL 5.0589 mL
20 mM 0.1518 mL 0.7588 mL 1.5177 mL 3.7942 mL
25 mM 0.1214 mL 0.6071 mL 1.2141 mL 3.0354 mL
30 mM 0.1012 mL 0.5059 mL 1.0118 mL 2.5295 mL
40 mM 0.0759 mL 0.3794 mL 0.7588 mL 1.8971 mL
50 mM 0.0607 mL 0.3035 mL 0.6071 mL 1.5177 mL
60 mM 0.0506 mL 0.2529 mL 0.5059 mL 1.2647 mL
80 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9486 mL
100 mM 0.0304 mL 0.1518 mL 0.3035 mL 0.7588 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pivalopril81045-50-3Pivopril RHC 3659(S)匹伏普利Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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