MAP4K Inhibitors

TNIK, IC₅₀: 21 nM

MAP4K4, IC₅₀: 3.7 nM

GCK/MAP4K2, pIC₅₀: 6.50

GLK/MAP4K3, pIC₅₀: 4.95

MAP4K4, IC₅₀: 3 nM
MAP4K4, pIC₅₀: 8.55

KHS/MAP4K5, pIC₅₀: 6.36

MINK1/MAP4K6, pIC₅₀: 8.18

TNIK/MAP4K7, pIC₅₀: 7.96

HPK1, IC₅₀: 0.25 nM

MAP4K4, IC₅₀: 3.7 nM

HPK1

GLK/MAP4K3, IC₅₀: 140 nM

HPK1, IC₅₀: 2.6 nM

MAP4K2, IC₅₀: 21.7 nM

TNIK, Ki: 100 nM

MAP4K4, IC₅₀: 14.9 nM

HPK1

HPK1, IC₅₀: <10 nM

MAP4K4, IC₅₀: 7 nM

MAP4K5, IC₅₀: 9 nM

MAP4K6, IC₅₀: 1.1 μM

MAP4K2, IC₅₀: 18.2 nM

HPK1

MAP4K2

GLK/MAP4K3

MAP4K5

HPK1

HPK1

HPK1, IC₅₀: <100 nM

HPK1

MAP4K4, IC₅₀: 7 nM

MAP4K5, IC₅₀: 9 nM

MAP4K6, IC₅₀: 1.1 μM

HPK1, IC₅₀: 3.5 nM

HPK1, IC₅₀: 0.5 nM

HPK1, Ki: 0.8 nM

HPK1, Ki: <100 nM

MAP4K4, IC₅₀: 3.428 ± 0. μM

MAP4K4, EC₅₀: 5737 nM

HPK1, IC₅₀: 129 nM

HPK1, Ki: 1.7 nM

MAP4K4, IC₅₀: 12-120 nM

HPK1, IC₅₀: 0.32 nM