2. MAPK/ERK Pathway Immunology/Inflammation
  3. MAP4K Interleukin Related IFNAR
  4. HPK1-IN-43

HPK1-IN-43 (compound 9f) 是一个 HPK1 激酶抑制剂，IC50 值为 0.32 nM。HPK1-IN-43 可抑制 PBMC 细胞中下游蛋白 SLP-76 的磷酸化，并增强白细胞介素 2 (IL-2) 和干扰素-γ (IFN-γ) 的分泌。HPK1-IN-43 可用于癌症研究。

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HPK1-IN-43 Chemical Structure

HPK1-IN-43 Chemical Structure

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HPK1-IN-43 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research[1].

IC50 & Target

HPK1

0.32 nM (IC50)

SLP-76

 

IL-2

 

IFN-γ

 

体外研究
(In Vitro)

HPK1-IN-43 (compound 9f) (0-100 nM, 1-18 h) 抑制 Jurkat 和原代外周血单核细胞 (PBMC) 中 SLP76 的磷酸化，IC50 值分别为 147.9 nM 和 131.8 nM。HPK1-IN-43 可促进 PBMC 中 IL-2 和 IFN-γ 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HPK1-IN-43 相关抗体:
分子量

510.51

Formula

C26H25F3N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HPK1-IN-43 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-43MAP4KInterleukin RelatedIFNARMAPK Kinase Kinase KinaseILInterferon-α/β receptorInterferon-alpha/beta receptorPBMC cellhuman T lymphocytic leukemia Jurkat cellscancerInhibitorinhibitorinhibit

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产品名称：
HPK1-IN-43
目录号：
HY-161335
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