1. Signaling Pathways
  2. Apoptosis
  3. RIP kinase

RIP kinase

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing TRIF or DAI. RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase 相关产品 (28):

Cat. No. Product Name Effect Purity
  • HY-15760
    Necrostatin-1 Inhibitor 99.20%
    Necrostatin-1 (Nec-1) 是一种有效,选择性和可渗透细胞的坏死性凋亡 (necroptosis) 抑制剂,在Jurkat细胞中的 EC50 为490 nM。Necrostatin-1 (Nec-1) 通过抑制坏死性凋亡途径中 (RIP1) 激酶域起作用。
  • HY-101872
    GSK-872 Inhibitor 99.65%
    GSK-872 是 RIPK3 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50为1.8 nM,并抑制激酶活性,IC50为1.3 nM。
  • HY-101760
    GSK2982772 Inhibitor >98.0%
    GSK2982772是可口服的、有效的ATP竞争型的RIP1酶抑制剂,对人和猴子 RIP1 的IC50值分别为16 nM 和 20 nM。
  • HY-101032
    RIPA-56 Inhibitor 99.86%
    RIPA-56是一种高效选择和代谢稳定的受体相互作用蛋白1 (RIP1) 抑制剂, 其中IC50值为13nM。
  • HY-100339
    GSK583 Inhibitor 98.64%
    GSK583 是一种高效,高选择性的 RIP2 Kinase 抑制剂,其 IC50 值为 5 nM。
  • HY-114349
    HS-1371 Inhibitor 98.49%
    HS-1371是高效,ATP-competitive的受体相互作用蛋白3 (RIP3)抑制剂,IC50 为 20.8 nM。
  • HY-104021
    GSK840 Inhibitor >98.0%
    GSK840 (GSK'840) 是一种受体相互作用蛋白激酶 3 (RIP3 or RIPK3) 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50 值为 0.9 nM,并抑制激酶活性,IC50 值为 0.3 nM。
  • HY-125402
    GSK-843 Inhibitor >98.0%
    GSK-843 (GSK'843) 是一种受体相互作用蛋白激酶 3 (RIP3 or RIPK3) 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50 值为 8.6 nM,并抑制激酶活性,IC50 值为 6.5 nM。
  • HY-18937
    WEHI-345 Inhibitor 98.56%
    WEHI-345是一种有效的选择性RIPK2, IC50为0.13 μM。
  • HY-14622
    Necrostatin 2 Inhibitor 99.97%
    Necrostatin 2 是一种有效的程序性坏死 (necroptosis) 抑制剂。作用于TNF-α处理的FADD缺陷型Jurkat T细胞,抑制程序性坏死,EC50 为 0.05 μM。Necrostatin 2 为 RIPK1 抑制剂。
  • HY-14622A
    Necrostatin 2 racemate Inhibitor 99.10%
    Necrostatin 2 racemate 是高活性的坏死性凋亡抑制剂,为有效的 RIPK1 抑制剂,缺乏 IDO 靶向作用。
  • HY-19764
    RIP2 kinase inhibitor 1 Inhibitor 98.24%
    RIP2 kinase inhibitor 1 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043446 A1 中的化合物 example 1。
  • HY-19761
    RIP2 kinase inhibitor 2 Inhibitor 99.95%
    RIP2 kinase inhibitor 2 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043437 A1 中的化合物 example 9。
  • HY-100131
    GSK'481 Inhibitor >98.0%
    GSK'481能够在HEK293T细胞中抑制RIP1 WT S166的磷酸化。
  • HY-14622B
    Necrostatin 2 S enantiomer Inhibitor 99.83%
    Necrostatin 2 S enantiomer 是 Necrostatin 2 的 S 型异构体。Necrostatin 2 是高活性的坏死性凋亡抑制剂,为有效的 RIPK1 抑制剂,缺乏 IDO 靶向作用。
  • HY-122909
    GSK2593074A Inhibitor
    GSK2593074A (GSK’074) 是一种程序性坏死 (necroptosis) 抑制剂, 抑制 RIP1RIP3
  • HY-114492
    GSK547 Inhibitor
    GSK547 (GSK'547) 是一种高效的选择性 receptor-interacting serine/threonine protein kinase 1 (RIP1) 抑制剂,可抑制巨噬细胞介导的胰腺癌适应性免疫耐受。
  • HY-112038A
    GSK2983559 Inhibitor
    GSK2983559 (compound 3) 是一种高效、特异性的,口服有效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂,在体内和人类炎症性肠病外植体样本中,具有良好的阻断多种促炎细胞因子反应活性。
  • HY-107978
    RIPK-IN-4 Inhibitor
    RIPK-IN-4 是一种有效选择性的、具有良好的口服生物利用度的 RIPK2 抑制剂,IC50 值为 3 nM。
  • HY-112907
    RIP2 Kinase Inhibitor 3 Inhibitor
    RIP2 Kinase Inhibitor 3 是一种高效、选择性的受体相互作用蛋白 -2 (RIP2) 激酶抑制剂,IC50 值为 1 nM。
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