2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Wee1

Wee1 (Wee1蛋白激酶)

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G2/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.
WEE1 subfamily includes PMYT1.

Wee1 亚型特异性产品:

Wee1 Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-144999
    LEB-03-146 98.08%
    LEB-03-146 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过 PEG2 连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。LEB-03-146 在 HEP3B 肝癌细胞中可显著稳定 WEE1。
    LEB-03-146
  • HY-145666
    Myt1-IN-3 Inhibitor 99.14%
    Myt1-IN-3 是一种有效的 膜相关酪氨酸和苏氨酸特异性 cdc2 抑制激酶 (Myt1) (Gene name PKMYT1) 抑制剂，IC50 小于 10 nM (WO2021195782 A1, compound 95)。
    Myt1-IN-3
  • HY-148065
    FMF-06-098-1 Inhibitor 98.77%
    FMF-06-098-1 是一种多靶点激酶 PROTAC 降解剂。FMF-06-098-1 可以降解 AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1，WEE1 (粉色：靶蛋白配体 (HY-169396)；蓝色：VHL 配体 (HY-112078)；黑色：连接体 (HY-124380))。
    FMF-06-098-1
  • HY-163490
    PKMYT1-IN-1 Inhibitor
    PKMYT1-IN-1 (Compound 1) 是膜相关酪氨酸和苏氨酸激酶 (PKMYT1) 的抑制剂，IC50 为 8.8 nM。PKMYT1-IN-1 抑制肿瘤细胞 HCC1569 的增殖，IC50 为 42 nM。
    PKMYT1-IN-1
  • HY-145665
    Myt1-IN-2 Inhibitor
    Myt1-IN-2 是一种有效的 膜相关酪氨酸和苏氨酸特异性 cdc2 抑制激酶 (Myt1) (Gene name PKMYT1) 抑制剂，IC50 <10 nM。Myt1-IN-2 具 有抗癌作用。
    Myt1-IN-2
  • HY-163491
    PKMYT1-IN-2 Inhibitor
    PKMYT1-IN-2 (compound 2) 是一种有效的 PKMYT1 抑制剂，IC50 为 5.7 nM。PKMYT1-IN-2 抑制 HCC1569 细胞的生长，IC50 为 22 nM。
    PKMYT1-IN-2
  • HY-168180
    WEE1-IN-11 Inhibitor
    WEE1-IN-11 (Compound 13) 是一种有效的 CDK2 抑制剂，其 IC50为 2.0 nM。WEE1-IN-11 对 NCI-H446、A427、OVCAR3、C33A 和 WiDr 细胞有抑制作用，IC50 分别为 93.9、34.5、86.7、23.1 和 85 nM。
    WEE1-IN-11
  • HY-161871
    WEE1-IN-8 Inhibitor
    WEE1-IN-8 (Compound 55) 是选择性的 WEE1 抑制剂，其 IC50 值为 0.98 nM。WEE1-IN-8 (Compound 55) 可用于胰腺癌、卵巢癌、结肠癌、子宫浆液癌等多种癌症研究。
    WEE1-IN-8
  • HY-161879
    WEE1-IN-9 Inhibitor
    WEE1-IN-9 (Compound 1) 是一种 Wee1 抑制剂，可以用于癌症的研究。
    WEE1-IN-9
  • HY-157443
    Myt1-IN-4 Inhibitor
    Myt1-IN-4 (21) 是具有口服活性的、选择性的 膜相关酪氨酸和苏氨酸特异性 cdc2 抑制激酶 (Myt1) (Gene name PKMYT1) 抑制剂，其IC50 值为2.6 nM。Myt1-IN-4 (21) 具有抗肿瘤活性。
    Myt1-IN-4
  • HY-168654
    WEE1 degrader 1 Degrader
    WEE1 degrader 1 (Compound 10) 是 Wee1 降解剂，对 Wee1 的 DC50 值为 1.5 nM。WEE1 degrader 1 具有抗癌细胞增殖作用。
    WEE1 degrader 1
  • HY-160530
    WEE1-IN-6 Inhibitor
    WEE1-IN-6 (compound 110) 是一种口服活性 WEE1 抑制剂，DC50 值≤ 100 nM。WEE1-IN-6 抑制细胞增殖。
    WEE1-IN-6
  • HY-162849
    PKMYT1-IN-3 Inhibitor
    PKMYT1-IN-3 (compound 8ma) 是一种有效和选择性的 PKMYT1 抑制剂，IC50 值为 16.5 nM。PKMYT1-IN-3 具有抗肿瘤活性。
    PKMYT1-IN-3
  • HY-172807
    p38α inhibitor 9 Inhibitor
    p38α inhibitor 9 (Compound 2015) 是一种 p38α 抑制剂，可阻断 p38α 的酶活性，其 IC50 低于 20 nM。p38α inhibitor 9 可抑制 MK2T334 磷酸化。p38α inhibitor 9 可激活 Cdc25b 和 Cdc25c，同时使 Wee1 失活，导致有丝分裂灾难、非整倍体或多倍体以及 DNA 损伤。p38α inhibitor 9 可抑制结直肠癌 (CRC) 转移。
    p38α inhibitor 9
  • HY-143342
    LEB-03-144
    LEB-03-144 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过 C3 烷基连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。LEB-03-144 在 HEP3B 肝癌细胞中可显著稳定 WEE1。
    LEB-03-144
  • HY-13925A
    PD0166285 dihydrochloride Inhibitor
    PD0166285 dihydrochloride是 P-gp 的一个底物，是 WEE1 抑制剂，也可微弱抑制 Myt1，IC50 值分别为 24 和 72 nM。PD0166285 dihydrochloride 对 Chk1 的 IC50 值为3.433 μM。
    PD0166285 dihydrochloride
  • HY-161880
    WEE1-IN-10 Inhibitor
    WEE1-IN-10 (compound 77) 是一种 Wee1 激酶抑制剂。WEE1-IN-10 对 LOVO 细胞生长有抑制活性，IC50 为 0.524 μM。WEE1-IN-10 可用于研究由 Wee1 活性异常引起的疾病。
    WEE1-IN-10
  • HY-169946
    WEE1/PKMYT1-IN-1 Inhibitor
    WEE1/PKMYT1-IN-1 (compound 75) 是一种有效且具有口服活性的 WEE1 和 PKMYT1 抑制剂。WEE1/PKMYT1-IN-1 表现出抗增殖活性。
    WEE1/PKMYT1-IN-1
  • HY-143343
    LEB-03-153
    LEB-03-153 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过无连接剂将 AZD1775 (Adavosertib) 连接到 OTUB1 的招募者 EN523。
    LEB-03-153
  • HY-143340
    LEB-03-145
    LEB-03-145 是一个 WEE1 DUBTAC (去泛素化酶靶向嵌合体)，通过 C5 烷基连接剂将 AZD1775 (Adavosertib) 与 OTUB1 招募者 EN523 连接起来。
    LEB-03-145
Wee1 Isoform Comparison

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