2. Immunology/Inflammation
  3. CD28
  4. Lulizumab

Lulizumab  (Synonyms: 鲁利珠单抗; Humanized Anti-CD28 Recombinant Antibody)

目录号: HY-P99302 纯度: ≥95.0%
COA 技术支持

Lulizumab (Humanized Anti-CD28 Recombinant Antibody) 是一种抗 CD28 结构域抗体拮抗剂。Lulizumab 通过选择性靶向 CD28 信号抑制 T 细胞激活。Lulizumab 在致敏非人灵长类肾移植模型中，与 Carfilzomib (HY-10455) 联用可调节免疫细胞、延长移植物存活时间。

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CAS No. : 2235419-62-0

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Lulizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lulizumab (Humanized Anti-CD28 Recombinant Antibody) is an anti-CD28 domain antibody antagonist. Lulizumab inhibits T-cell activation by selectively targeting the CD28 signal. In a sensitized non-human primate kidney transplantation model, when combined with Carfilzomib (HY-10455), Lulizumab can regulate immune cells and prolong the survival time of the graft[1][2].

同型

V-kappa
反应种属

Human
IC50 & Target

CD28
体内研究
(In Vivo)

Lulizumab (12.5 mg/kg; 皮下注射; 每周 1 次; 4 周) 在致敏非人灵长类 (恒河猴) 肾移植模型中，与 Carfilzomib (HY-10455) 联合使用，能降低供体特异性抗体水平，调节免疫细胞，延长移植物存活时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Macaca mulatta were sensitized by performing swapping skin transplants of 3cm diameter patches of dorsal skin between individuals of each pair twice, 8 weeks apart. Then they underwent kidney transplantation[2].
Dosage: 12.5 mg/kg
Administration: Subcutaneous injection; once a week for 4 weeks
Result: Led to a significant reduction in donor-specific antibody levels.
Decreased the number of follicular helper T cells and proliferating B cells in the lymph nodes.
Increased the proportion of naïve CD4 T cells and naïve B cells in circulation, maintained the frequency of regulatory T cells.
Significantly prolonged the median survival time of the grafts.
Caused animals to ultimately experience antibody-mediated rejection and graft failure.
Clinical Trial
基因 ID

940  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

12.01 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

鲁利珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Flow cytometric analysis of 106 Jurkat cells with Lulizumab (HY-P99302, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).
纯度 & 产品资料

纯度: ≥95.0%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Lulizumab 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lulizumab2235419-62-0Humanized Anti-CD28 Recombinant Antibody鲁利珠单抗CD28T cellrhesus macaquekidney transplantation modelInhibitorinhibitorinhibit

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