2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Glycine Receptor (GlyR) iGluR
  4. ZD 9379 sodium

ZD 9379 sodium 是一种竞争性甘氨酸/NMDA 受体 (glycine/NMDA receptor) 拮抗剂，IC50 (谷氨酸位点) 为 75 nM。ZD 9379 sodium 选择性拮抗 NMDA 受体上的甘氨酸结合位点 (GlyB 位点)，抑制甘氨酸与 NMDA 受体结合，缓解兴奋性毒性。ZD 9379 sodium 通过抑制皮质扩散性抑制 (SDs) 的频次，减轻缺血半暗带能量耗竭，延缓梗死扩展。ZD 9379 sodium 在小鼠模型中减少梗死体积并改善神经功能。ZD 9379 sodium 可用于急性缺血性卒中等研究。

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ZD 9379 sodium

ZD 9379 sodium Chemical Structure

CAS No. : 170142-29-7

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ZD 9379 sodium 相关抗体

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生物活性

ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc[1][2].

体内研究
(In Vivo)

ZD 9379 (5 mg/kg, i.v., 灌注 4 小时) sodium 在大鼠永久性大脑中动脉闭塞 (MCAO) 模型中显著减少梗死体积，抑制 SDs，改善神经功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO model established in male Sprague-Dawley rats (weighing 290-340 grams)[1]
Dosage: 5 mg/kg
Administration: Intravenous injection (i.v.), for 4 hours
Result: Significantly reduced infarction volume, and the number of SDs was significantly decreased.
Significantly improved neurological scores, without causing significant changes in physiological parameters or behavioral side effects.
分子量

406.77

Formula

C19H15ClN3NaO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZD 9379 sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZD 9379170142-29-7ZD9379ZD-9379Glycine Receptor (GlyR)iGluRGlycine ReceptorIonotropic glutamate receptorscerebral ischemiamiddle cerebral artery occlusionN-methyl-D-aspartatespreading cortical depressionratsInhibitorinhibitorinhibit

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