1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Methylenetetrahydrofolate Dehydrogenase (MTHFD) (亚甲基四氢叶酸脱氢酶)

Methylenetetrahydrofolate dehydrogenase (MTHFD) is a key enzyme in the folate-dependent one carbon metabolism, which is important for the biosynthesis of several amino acids like glycine, alanine and serine, as well as nucleotide bases, formylated methionine and some pro-vitamins. In some bacteria like E. coli, MTHFD (called FolD in this species) is a dual function enzyme that catalyzes the conversion of 5,10-methylenetetrahydrofolate and NADP+ to 5,10-methenyltetrahydrofolate and NADPH (dehydrogenase function), and further converts the first product to 10-formyltetrahdrofolate (cyclohydrolase function). Some microorganisms have a separate enzyme for catalyzing the second cyclohydrolase function (FchA), and some species have an alternative pathway for 10-formyltetrahdrofolate production using formyltetrahydrofolate synthetase (Fhs). In eukaryotes, MTHFD is an important anticancer therapy target.

Methylenetetrahydrofolate Dehydrogenase (MTHFD) 相关产品 (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-130251
    DS18561882 99.87%
    DS18561882 是一种高效的,对酶具有高选择性的亚甲基四氢叶酸脱氢酶 2 ( MTHFD2) 抑制剂,IC50 值为 0.0063 μM。DS18561882 抑制 MTHFD1 的 IC50 值是 0.57 μM。DS18561882 具有良好的口服药代动力学特性。
    DS18561882
  • HY-101943
    LY 345899 ≥98.0%
    LY 345899 是一种叶酸的类似物,也是一种亚甲基四氢叶酸脱氢酶 (MTHFD1; DC301) 和 MTHFD2 抑制剂,其 IC50 值分别为 96 nM 和 663 nM,对 MTHFD1Ki 值为 18 nM。
    LY 345899
  • HY-131943
    DS44960156 99.36%
    DS44960156 是选择性的亚甲基四氢叶酸脱氢酶 2 (MTHFD2) 的抑制剂,其对 MTHFD2 和 MTHFD1 的 IC50 值分别为 1.6 μM 和 >30 μM。
    DS44960156
  • HY-155950
    TH9619 Inhibitor 99.33%
    TH9619 是 MTHFD2 抑制剂,IC50 值为 47 nM。TH9619 通过阻滞 S期,诱导细胞凋亡 (apoptosis)。TH9619 具有抗肿瘤活性。
    TH9619
  • HY-149828
    MTHFD2-IN-4 Inhibitor
    MTHFD2-IN-4 是一种三环香豆素衍生物,是一种有效的 MTHFD2 抑制剂。MTHFD2-IN-4 可用于癌症研究。
    MTHFD2-IN-4
  • HY-149825
    MTHFD2-IN-1 Inhibitor
    MTHFD2-IN-1 (compound 12) 是一种有效的亚甲基四氢叶酸脱氢酶 (MTHFD2) 抑制剂。
    MTHFD2-IN-1
  • HY-149826
    MTHFD2-IN-2 Inhibitor
    MTHFD2-IN-2 (compound 13) 是一种有效的亚甲基四氢叶酸脱氢酶 (MTHFD2) 抑制剂。
    MTHFD2-IN-2
  • HY-149828A
    MTHFD2-IN-4 sodium Inhibitor
    MTHFD2-IN-4 sodium 是一种三环香豆素衍生物,是一种有效的 MTHFD2 抑制剂。MTHFD2-IN-4 sodium 可用于癌症研究。
    MTHFD2-IN-4 sodium
  • HY-149827
    MTHFD2-IN-3 Inhibitor
    MTHFD2-IN-3 (compound 10) 是一种有效的亚甲基四氢叶酸脱氢酶 (MTHFD2) 抑制剂。
    MTHFD2-IN-3