2. Immunology/Inflammation
  3. Interleukin Related
  4. Ustekinumab

Ustekinumab  (Synonyms: 乌司奴单抗)

目录号: HY-P9909 纯度: 98.42%
COA 技术支持

Ustekinumab 是一种抗 IL-12/IL-23 的人源单克隆 IgG1κ 抗体。

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CAS No. : 815610-63-0

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Ustekinumab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

IC50 & Target

IL-12

 

IL-23

 

体外研究
(In Vitro)

Ustekinumab 是一种人源化单克隆抗体，可阻止人 IL-12 和 IL-23 与自然杀伤细胞和 T 细胞表面 IL-12 (IL-12Rβ1/β2) 和 IL-23(IL-12Rβ1/23R) 受体复合物的 IL-12Rβ1 受体链结合[1]。
Ustekinumab 是一种针对 IL-12/IL-23 p40 亚基的人源化 IgG1 κ(κ) 单克隆抗体，可阻止其与 IL-12Rβ1 相互作用，从而阻断后续信号传导。在 pH 6.0 下，所有 11 种抗体的 FcRn 亲和力均在一个较窄的范围内。平衡解离常数 (KD) 是相对于 Ustekinumab 计算的[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ustekinumab 相关抗体:
Clinical Trial
分子量

145.63 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

尤特克单抗； 乌司奴单抗； 优特克单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-12 beta Protein, Human (HEK293, Fc, HY-P73160) can bind Ustekinumab. The EC50 for this effect is 13.6 ng/mL.
纯度 & 产品资料

纯度: 98.42%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献
Cell Assay
[2]

HUVECs are grown on calibrated glass coverslips to a confluency of 80%. Subsequently, cells are incubated with 200 µg/mL Ustekinumab AlexaFluor488 and Briakinumab AlexaFluor594 for 20 min at 37°C, pH 7.3, washed three times, and chased in fresh medium for an additional 20 min before fixation. Antibodies are directly labeled. FcRn binding is quality controlled by SPR analysis. Cells are then counterstained with anti-FcRn monoclonal antibody DVN22, followed by anti-mouse secondary antibodies conjugated to AlexaFluor647. Imaging is performed on a Leica SP8 confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Ustekinumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ustekinumab815610-63-0尤特克单抗 乌司奴单抗 优特克单抗Interleukin RelatedILInhibitorinhibitorinhibit

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