1. Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  2. Cholinesterase (ChE) Histamine Receptor
  3. AChE-IN-14

AChE-IN-14 (compound 5) 是一种有效的胆碱酯酶抑制剂,对电鳗乙酰胆碱酯酶 (eeAChE)、人重组乙酰胆碱酯酶 (hAChE) 和马血清丁酰胆碱酯酶 (eqBuChE) 的 IC50 分别为 0.46、0.48 和 0.44 μM。AChE-IN-14 对人 H3 受体 (H3R) 具有高亲和力,Ki 为 159.8 nM。AChE-IN-14 可用于阿尔茨海默病的研究。

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AChE-IN-14 Chemical Structure

AChE-IN-14 Chemical Structure

CAS No. : 2390042-05-2

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  • 生物活性

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生物活性

AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1].

体外研究
(In Vitro)

AChE-IN-14 (compound 5) has a good affinity to human H3 receptor with a Ki value of 159.8 nM in HEK293 cells[1].
AChE-IN-14 has a high orally activity and cannot cross the blood-brain barrier[1].
AChE-IN-14 (10 μM, 5 min) inhibits hAChE with an IC50 value of 0.48 μM and represents the non-competitive type of eeAChE (Ki = 176 nM) and eqBuChE (Ki = 281 nM) inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

433.58

Formula

C28H35NO3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AChE-IN-14
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HY-146035
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