1. Immunology/Inflammation Apoptosis
  2. PD-1/PD-L1 Apoptosis
  3. Adebrelimab

Adebrelimab  (Synonyms: SHR-1316)

目录号: HY-P99422 纯度: 97.84%
COA

Adebrelimab (SHR-1316) 是一种人源化 IgG4 单克隆 PD-L1 (PD-1/PD-L1) 抗体。Adebrelimab 在包括广泛期小细胞肺癌 (SCLC) 在内的实体瘤中具有良好的抗肿瘤活性。

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Adebrelimab Chemical Structure

Adebrelimab Chemical Structure

CAS No. : 2247114-85-6

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  • 生物活性

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生物活性

Adebrelimab (SHR-1316) is a humanized IgG4 monoclonal PD-L1 (PD-1/PD-L1) antibody. Adebrelimab has promising antitumor activity in solid tumors including extensive-stage small-cell lung cancer (SCLC)[1][2].

体外研究
(In Vitro)

Adebrelimab (SHR-1316; 0.06- 1mg/mL; 48 hours) 抑制 SK-BR-3 和 AU565 细胞的增殖、迁移、侵袭[1]
Adebrelimab(SHR-1316;0.1-1mg/mL;48 小时)下调 PD-L1、p-PI3K、p-AKT 的表达并上调 FOXO1 的表达[1]。 SK-BR-3 and AU565 cells 0.1 mg/mL, 1 mg/mL 48 hours Promoted cell apoptosis. SK-BR-3 and AU565 cells 0.1 mg/mL, 1 mg/mL 24 hours Decreased the migration rate of SK-BR -3 and AU565 cells. SK-BR-3 and AU565 cells 0.1 mg/mL, 1 mg/mL 48 hours Downregulated the expression of PD-L1, p-PI3K, p-AKT and upregulated the expression FOXO1.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.06 mg/mL, 0.13 mg/mL, 0.25 mg/mL, 0.5 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: The viability of SK-BR-3 and AU565 cells decreased gradually.

Apoptosis Analysis[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Promoted cell apoptosis.

Cell Migration Assay [1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Decreased the migration rate of SK-BR -3 and AU565 cells.

Western Blot Analysis[1]

Cell Line: SK-BR-3 and AU565 cells
Concentration: 0.1 mg/mL, 1 mg/mL
Incubation Time: 48 hours
Result: Downregulated the expression of PD-L1, p-PI3K, p-AKT and upregulated the expression FOXO1.
体内研究
(In Vivo)

Adebrelimab(SHR-1316;200 μg;每周 3 次;持续 21 天)显示出对肿瘤生长的抑制作用[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen free (SPF) BALB/c nude female mice (aged 5-6 weeks) injected with SK-BR-3 cells[1]
Dosage: 200 μg
Administration: Three times a week; for 21 days
Result: Significantly inhibited tumor growth.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-P99422
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