2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Alirocumab

Alirocumab  (Synonyms: REGN 727; SAR 236553)

目录号: HY-P9928 纯度: 97%
COA

摩尔计算器

Alirocumab (REGN 727) 是一种 PCSK9 的人单克隆抗体抑制剂。Alirocumab 是一种单克隆抗体。Alirocumab 有抗炎、抗血管生成和抗氧化作用。Alirocumab 可用于高胆固醇血症的研究。

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Alirocumab Chemical Structure

Alirocumab Chemical Structure

CAS No. : 1245916-14-6

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规格 价格 是否有货 数量
1 mg ￥4200
In-stock
5 mg ￥9400
In-stock
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50 mg   询价  

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Alirocumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia[1][2][3][4][5].

体外研究
(In Vitro)

Alirocumab (0.01, 0.1, 1, 2和10 μM, 24-72 h) 在 hiPSC-CMs 和 hESC-CMs 中不影响细胞活力和功能，可用于评估降脂心血管细胞中的药物安全性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alirocumab 相关抗体:

Cell Viability Assay[3]

Cell Line: hiPSC-CMs, hESC-CMs
Concentration: 0.01, 0.1, 1, 2, 10 μM
Incubation Time: 24-72 h
Result: Exhibited normal cell viability and did not affect the level of LDH release.
体内研究
(In Vivo)

Alirocumab (3或10 mg/kg, 每周皮下注射持续18周) 在小鼠中可抑制动脉粥样硬化，改善斑块形态，增强他汀类药物的作用[4]。
Alirocumab (10 mg/kg, 第 0, 10, 20 天腹腔注射) 在大鼠中可通过抑制 PCSK9 改善 BDL 诱导的肝硬化大鼠的全身氧化应激和高脂血症[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CETP mice model[4]
Dosage: 3 or 10 mg/kg
Administration: s.c.
Result: Decreased total cholesterol dose-dependently.
Increased hepatic LDL receptor protein levels but did not affect hepatic cholesterol and TG content.
Decreased atherosclerotic lesion size and improved plaque morphology.
Animal Model: Rat model (240-280 g) [5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Elevated ammonia, total cholesterol, LDL and ox-LDL levels.
Decreased plasma levels of total cholesterol, LDL, and oxidative stress markers.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 97%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Alirocumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alirocumab1245916-14-6REGN 727 SAR 236553REGN727REGN-727SAR236553SAR 236553SAR-236553Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesPraluentPCSK9InhibitorhiPSC-CMshESC-CMsLDLCETP mice modelAnti-inflammatoryinhibitorinhibit

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