2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. PPAR Apoptosis
  4. Ankaflavin

Ankaflavin 是从 Monascus-Fermented 红米中提取得到的，是一种具有口服活性的 PPARγ 的激动剂。Ankaflavin 具有选择性的细胞毒性作用，诱导癌细胞凋亡（apoptosis）。Ankaflavin 具有抗炎、抗癌、抗动脉粥样硬化和降血脂的作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ankaflavin Chemical Structure

Ankaflavin Chemical Structure

CAS No. : 50980-32-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3200
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ankaflavin 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

查看所有亚型
PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects[1][2].

IC50 & Target

PPARγ[2].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
7.05 μM
Compound: 6
Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
[PMID: 20655237]
IGROV-1 IC50
5.08 μM
Compound: 6
Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
[PMID: 20655237]
NCI-H460 IC50
30 μM
Compound: 6
Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
[PMID: 20655237]
体外研究
(In Vitro)

Ankaflavin (0-50 µg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells[1].
Ankaflavin (0-30 µg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner[1].
Ankaflavin (25 µg/mL, 48 h) induces Hep G2 cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ankaflavin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, Hep G2, MRC-5 and WI-38
Concentration: 1, 10, 25, and 50 µg/mL
Incubation Time: 48 h
Result: Showed cytotoxicity against A549 and Hep G2 cells in a dose-dependent manner with no significant toxicity toward normal cells (MRC-5 and WI-38).

Cell Cycle Analysis[1]

Cell Line: Hep G2 cells
Concentration: 15, 20, 25, and 30 µg/mL
Incubation Time: 12, 24, 36, and 48 h
Result: Induced a distinct sub-G1 peak in Hep G2 cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: Hep G2 cells
Concentration: 25 µg/mL
Incubation Time: 48 h
Result: Exhibited significant chromatin condensation (fluorescent spot) through Hoechst staining.
体内研究
(In Vivo)

Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks[2]
Dosage: 10 mg/kg
Administration: Oral administration for 28 days
Result: Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.
分子量

386.48

同用名

红曲黄素

Formula

C23H30O5
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

红曲黄素
结构分类
初始来源

Monascus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Ankaflavin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ankaflavin50980-32-0红曲黄素PPARApoptosisPeroxisome proliferator-activated receptorsHep G2A549anticancerantioxidantantidiabeticanti-inflammatoryantiatherosclerotichypolipidemic effectInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ankaflavin
目录号：
HY-N6642
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z