1. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  2. PPAR Apoptosis
  3. Ankaflavin

Ankaflavin 是从 Monascus-Fermented 红米中提取得到的,是一种具有口服活性的 PPARγ 的激动剂。Ankaflavin 具有选择性的细胞毒性作用,诱导癌细胞凋亡(apoptosis)。Ankaflavin 具有抗炎、抗癌、抗动脉粥样硬化和降血脂的作用。

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Ankaflavin Chemical Structure

Ankaflavin Chemical Structure

CAS No. : 50980-32-0

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规格 价格 是否有货 数量
1 mg ¥3200
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Customer Review

查看 PPAR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects[1][2].

IC50 & Target

PPARγ[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
7.05 μM
Compound: 6
Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
[PMID: 20655237]
IGROV-1 IC50
5.08 μM
Compound: 6
Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
[PMID: 20655237]
NCI-H460 IC50
30 μM
Compound: 6
Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
[PMID: 20655237]
体外研究
(In Vitro)

Ankaflavin (0-50 µg/mL, 48 h) shows cytotoxicity against cancer cells with no significant toxicity toward normal cells[1].
Ankaflavin (0-30 µg/mL, 0-48 h) arrests Hep G2 cell cycle at sub-G1 phase in a dose- and time-dependent manner[1].
Ankaflavin (25 µg/mL, 48 h) induces Hep G2 cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549, Hep G2, MRC-5 and WI-38
Concentration: 1, 10, 25, and 50 µg/mL
Incubation Time: 48 h
Result: Showed cytotoxicity against A549 and Hep G2 cells in a dose-dependent manner with no significant toxicity toward normal cells (MRC-5 and WI-38).

Cell Cycle Analysis[1]

Cell Line: Hep G2 cells
Concentration: 15, 20, 25, and 30 µg/mL
Incubation Time: 12, 24, 36, and 48 h
Result: Induced a distinct sub-G1 peak in Hep G2 cells in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: Hep G2 cells
Concentration: 25 µg/mL
Incubation Time: 48 h
Result: Exhibited significant chromatin condensation (fluorescent spot) through Hoechst staining.
体内研究
(In Vivo)

Ankaflavin (10 mg/kg; p.o.; daily for 28 days) shows antidiabetic and anti-inflammatory activity, improves liver function and pancreatic function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (4 weeks of age), diabetes was induced by treating them with Methylglyoxal (MG) (600 mg/kg; oral) for 4 weeks[2]
Dosage: 10 mg/kg
Administration: Oral administration for 28 days
Result: Exerted PPARγ agonist activity. Effectively reduced AGE (advanced glycation end-products) levels in serum, liver, and pancreas of MG-induced rats.
分子量

386.48

同用名

红曲黄素

Formula

C23H30O5

CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

红曲黄素

结构分类
初始来源

Monascus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ankaflavin
目录号:
HY-N6642
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