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  4. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13)

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 

目录号: HY-P990835 纯度: 95.00%
COA 技术支持

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 是一种鼠源 IgG1 嵌合抗体抑制剂，靶向人 LFA-1α/CD11a。Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 可与人 LFA-1α (淋巴细胞功能相关抗原 1α，也称为整合素 αL 链和 CD11a) 发生反应。Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 可用于免疫学和感染方面的研究，例如人类免疫缺陷病毒 (HIV)。

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Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13)

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) Chemical Structure

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Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 相关抗体

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

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  • 参考文献

生物活性

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human LFA-1α/CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) reacts with human LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) can be used for the researches of immunology and infection, such as human immunodeficiency virus (HIV)[1][2].

同型

Mouse IgG1 kappa
反应种属

Human
IC50 & Target

LFA-1α/CD11a
体外研究
(In Vitro)

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) (250 µg/mL, 6 h) 与贝拉西普 (HY-108813) 联合使用时，可减少人外周血单核细胞中同种反应性记忆 T 细胞产生的 IFN-γ[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 相关抗体:
体内研究
(In Vivo)

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) (125 µg，腹腔注射，从 CD8+ T 细胞人源化前 2 天开始，每隔一天注射一次，持续 4 周) 在成年 NOD/SCID/IL-2rcγ-/- (NSG) 小鼠中显示出抗人类免疫缺陷病毒 (HIV) 感染的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Highly purified and activated CD8+ T cells were injected into adult NOD/SCID/IL-2rcγ-/- (NSG) mice with human immunodeficiency virus (HIV) infection[1]
Dosage: 125 μg
Administration: Intraperitoneally injection, every other day for 4 weeks from day 2 prehumanization with CD8+ T cells
Result: Exhibited significantly lower levels of human lymphocytes in the CNS and in the spleen.
Reduced levels of HIV DNA in the brain and spleen.
基因 ID

16408  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13)IntegrinLFA-1αCD11aHIVIFN-γT cellsInhibitorinhibitorinhibit

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