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Belatacept  (Synonyms: BMS 224818; LEA 29Y)

目录号: HY-108813 纯度: 98.00%
COA 产品使用指南

摩尔计算器

Belatacept (BMS 224818) 是一种选择性 T 细胞共刺激 (T-cell costimulation) 阻滞剂。Belatacept 与 CD 80/86 配体结合而抑制 CD-28 介导的 T 细胞共刺激。Belatacept 可用于器官移植免疫抑制的研究。

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Belatacept Chemical Structure

Belatacept Chemical Structure

CAS No. : 706808-37-9

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规格 价格 是否有货 数量
1 mg ￥2000
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5 mg ￥5600
In-stock
10 mg ￥9000
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Customer Review

Belatacept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belatacept (BMS 224818) is a selective T-cell costimulation blocker. Belatacept binds to CD 80/86 ligands and thereby inhibits the CD-28-mediated T-cell costimulation. Belatacept can be used in the research of Immunosuppression in organ transplants[1].

IC50 & Target

CD80/86[1]
体外研究
(In Vitro)

Belatacept (0-5 mg/mL, 1 h) inhibits T-cell proliferation in a dose-dependent manner[2].
Belatacept (500 ng/mL, 7 days) enhances predominance of effector-memory T-cells after allogeneic stimulation[2].
Belatacept (100, 500 ng/mL, 7 days) has no effect on differentiation and allogeneic IFNγ production of isolated effector-memory T cells[2].
Belatacept (10 μg/mL, 1 h) does not inhibit follicular T Cell-dependent B-Cell differentiation[4].
Belatacept (40 μg/mL, 10 days) reduces plasmablast differentiation, Ig production, and the major transcription factor Blimp-1 in a T cell-independent manner[5].
Belatacept (40 μg/mL, 30 min) induces activation of the STAT3 transcription factor in stimulated B cells and reduced the expression of CD86[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belatacept 相关抗体:

Cell Viability Assay[2]

Cell Line: PBMCs from healthy volunteers
Concentration: 0-5 mg/mL
Incubation Time: 1 h
Result: Inhibited T-cell proliferation l with IC50 values of 215 ng/mL, and residual T-cell proliferation (±30%) was still present at high doses.

Western Blot Analysis[5]

Cell Line: CD40L and IL-21 stimulated B cells
Concentration: 40 μg/mL
Incubation Time: 15, 30 min
Result: Increased in STAT signaling determined by increased STAT3 phosphorylation.
体内研究
(In Vivo)

Belatacept (intraperitoneal injection, 60 mg/kg) inhibits ABMR (Antibody-Mediated Rejection), and inhibits acute rejection when combined with BTLA (B and T lymphocyte attenuator) overexpression therapy[3].
Belatacept (intravenous injection, 20 mg/kg) displays immunosuppressive activities in monkeys immunized with sheep red blood cell[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute rejection model of orthotopic kidney transplantation in rats[3]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection, at postoperative and 4 days after transplantation.
Result: Inhibited creatinine increase after kidney transplantation (combined with BTLA overexpression therapy).
Reduced C4d in graft IF staining, and reduced CD138 infiltration and DSA production.
Animal Model: Rhesus monkeys immunized with sheep red blood cell[6]
Dosage: Intra-operatively 10 mg/kg, on day 4 (15 mg/kg) and on post-operative days 14, 28, 42, 56, 70 (20 mg/kg).
Administration: intravenous injection
Result: Caused a 50% reduction in the peak anti-SRBC response.
Prolonged renal allograft survival and synergies with conventional immunosuppression.
Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

中文名称

贝拉西普
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at 4°C, do not freeze
溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.00%

COA (149 KB)

产品使用指南 (1538 KB)
参考文献

Belatacept 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belatacept706808-37-9BMS 224818 LEA 29Y贝拉西普BMS224818BMS-224818OthersPBMCT-cellB cellseffector-memory T-cellskidney transplantationacute rejectionimmunosuppressantBTLAtransplantationInhibitorinhibitorinhibit

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