2. 抗体抑制剂
  3. 融合蛋白
  4. Belatacept

Belatacept  (Synonyms: BMS 224818; LEA 29Y)

目录号: HY-108813 纯度: 99.30%
COA 技术支持

Belatacept (BMS 224818) 是一种选择性 T 细胞共刺激 (T-cell costimulation) 阻滞剂，是 CD28-CD80/86 通路的共刺激剂。Belatacept 与 CD 80/86 配体结合而抑制 CD-28 介导的 T 细胞共刺激，产生 IFN-γ。Belatacept 可用于器官移植免疫抑制的研究。(Note: 下方产品规格仅指示 Belatacept 有效含量，该产品成分比例为 Belatacept : 辅料 = 1:2.4。)

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CAS No. : 706808-37-9

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规格 价格 是否有货 数量
1 mg ￥2000
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5 mg ￥5600
In-stock
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100 mg   询价  

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Belatacept 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation[1][2]. The component ratio of this product is Active ingredient : Excipients = 1:2.4.

IC50 & Target

CD80/86[1]
体外研究
(In Vitro)

Belatacept (0-5 mg/mL，1 小时) 以剂量依赖性方式抑制 T 细胞增殖[2]。
Belatacept (500 ng/mL，7 天) 在同种异体刺激后增强效应记忆 T 细胞的优势[2]。
Belatacept (100、500 ng/mL，7 天) 对分离的效应记忆 T 细胞的分化和同种异体 IFNγ 产生没有影响[2]。
Belatacept (10 μg/mL，1 小时) 不会抑制滤泡 T 细胞依赖性 B 细胞分化[4]。
Belatacept (40 μg/mL，10 天) 降低 T 细胞中的浆母细胞分化、免疫球蛋白产生和主要转录因子 Blimp-1 细胞非依赖性方式[5]。
Belatacept (40 μg/mL，30 分钟) 诱导受刺激的 B 细胞中 STAT3 转录因子的激活，并降低 CD86 的表达[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belatacept 相关抗体:

Cell Viability Assay[2]

Cell Line: PBMCs from healthy volunteers
Concentration: 0-5 mg/mL
Incubation Time: 1 h
Result: Inhibited T-cell proliferation l with IC50 values of 215 ng/mL, and residual T-cell proliferation (±30%) was still present at high doses.

Western Blot Analysis[5]

Cell Line: CD40L and IL-21 stimulated B cells
Concentration: 40 μg/mL
Incubation Time: 15, 30 min
Result: Increased in STAT signaling determined by increased STAT3 phosphorylation.
体内研究
(In Vivo)

Belatacept (腹膜内注射，60 mg/kg) 可抑制 ABMR (抗体介导排斥)，与 BTLA (B 和 T 淋巴细胞衰减剂) 过表达疗法联合使用时可抑制急性排斥[3]。
Belatacept (静脉注射，20 mg/kg) 在用绵羊红细胞免疫的猴子中显示出免疫抑制活性[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute rejection model of orthotopic kidney transplantation in rats[3]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection, at postoperative and 4 days after transplantation.
Result: Inhibited creatinine increase after kidney transplantation (combined with BTLA overexpression therapy).
Reduced C4d in graft IF staining, and reduced CD138 infiltration and DSA production.
Animal Model: Rhesus monkeys immunized with sheep red blood cell[6]
Dosage: Intra-operatively 10 mg/kg, on day 4 (15 mg/kg) and on post-operative days 14, 28, 42, 56, 70 (20 mg/kg).
Administration: intravenous injection
Result: Caused a 50% reduction in the peak anti-SRBC response.
Prolonged renal allograft survival and synergies with conventional immunosuppression.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

90 kDa

CAS 号
性状

固体

颜色

White to off-white

中文名称

贝拉西普
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Fusion - [CTLA4 (cytotoxic T-lymphocyte-associated protein 4, CD152)]2 - IGHG1 Fc (Fragment constant)
纯度 & 产品资料

纯度: 99.30%

COA (264 KB) SEC-HPLC (130 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Belatacept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belatacept706808-37-9BMS 224818 LEA 29Y贝拉西普BMS224818BMS-224818OthersPBMCT-cellB cellseffector-memory T-cellskidney transplantationacute rejectionimmunosuppressantBTLAtransplantationInhibitorinhibitorinhibit

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