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  4. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 

目录号: HY-P990296
技术支持

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 是一种源自大鼠的 IgG2b λ 型抗体抑制剂，靶向小鼠 CCR3/CD193。Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 可消耗嗜酸性粒细胞。Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 可用于癌症、感染、炎症和免疫学等方面的研究，如淋巴瘤、回肠炎和粪类圆线虫感染。

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Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) Chemical Structure

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Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 相关抗体

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) is a rat-derived IgG2b λ type antibody inhibitor, targeting to mouse CCR3/CD193. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can deplete eosinophils. Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) can be used for the researches of cancer, infection, inflammation and immunology, such as lymphoma, ileitis and strongyloides stercoralis infection[1][2][3][4].

同型

Rat IgG2b
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CCR3/CD193
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (感染前 1 天及感染后 2 天腹腔注射 350 μg，在植入时的扩散小室附近皮下注射 100 μg) 可消耗嗜酸性粒细胞，并提高感染粪类圆线虫 L3 期幼虫的小鼠中幼虫存活率[1]。
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (从 20 周龄至 30 周龄，每周腹腔注射 200 μg) 可消耗嗜酸性粒细胞，并减轻慢性回肠炎小鼠的回肠炎症状[2]。
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (在第 13 天和第 15 天腹腔注射 100 μg) 会阻碍抗 CD19 嵌合抗原受体 T 细胞在 A20 淋巴瘤小鼠中的抗肿瘤功效[3]。
Anti-Mouse CCR3/CD193) Antibody (6S2-19-4) (在注射 IL-5 前 1 天腹腔注射 1 mg) 可消除 BALB/c 野生型小鼠中 eotaxin-2 诱导的气道高反应性，并抑制 IL-13 的产生[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic ileitis mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, once a week from 20 to 30 weeks of age
Result: Decreased eosinophils and MLN cellularity.
Reduced CD4+ and CD8+ effector T cells.
Reduced lymphocyte chemokines CCL17, CCCL22 and CCR4.
基因 ID

12711  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CCR3/CD193 Antibody (6S2-19-4)CCRCC chemokine receptorCCR3CD193EosinophilsLymphomaLleitisStrongyloides stercoralisEotaxin-2Inhibitorinhibitorinhibit

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