2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD122/IL-2Rβ Antibody (5H4)

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 

目录号: HY-P990293
技术支持

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 CD122/IL-2Rβ。Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 可抑制 IL-2。Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 可用于癌症和免疫学研究，如肝细胞癌。

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Anti-Mouse CD122/IL-2Rβ Antibody (5H4)

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can inhibit IL-2. Anti-Mouse CD122/IL-2Rβ Antibody (5H4) can be used for the researches of cancer and immunology, such as hepatocellular carcinoma[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD122/IL-2Rβ
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg，腹腔注射，每 3 天一次) 可恢复肝细胞癌小鼠肿瘤特异性 CD8+ T 细胞活性并减轻肿瘤负荷[1]。
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg/mouse，腹腔注射，在第 7、9、12、14 和 16 天给药) 可减少 B6 小鼠中 CD8+CD122+ T 细胞群体[2]。
Anti-Mouse CD122/IL-2Rβ Antibody (5H4) (100 μg/mouse，腹腔注射，每 2-3 天一次，共 5 次) 在 B16-OVA 肿瘤小鼠模型中与肿瘤疫苗联合使用时可抑制肿瘤生长并延长生存期[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-OVA tumor mice models[1]
Dosage: 100 μg/mouse, companied with tumor vaccine
Administration: Intraperitoneally injection, every 2-3 days for 5 times
Result: Inhibited tumor growth with 10% long-term survival.
Reduced the frequency of G-MDSCs.
Increased the dual IFNγ/TNFα production from effector CD8+ TILs.
Enhanced the OVA-tetramer-specific CD8+CD44+ memory T cells in the tumors.
Reduced the frequency of CD4+ Tregs.
基因 ID

16185  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD122/IL-2Rβ Antibody (5H4) 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD122/IL-2Rβ Antibody (5H4)Transmembrane GlycoproteinCD122IL-2T cellsCancerHepatocellular carcinomaB16-OVAInhibitorinhibitorinhibit

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