2. Immunology/Inflammation
  3. CD20
  4. Anti-Mouse CD20 Antibody (MB20-11)

Anti-Mouse CD20 Antibody (MB20-11) 

目录号: HY-P990806 纯度: 95.00%
COA 技术支持

Anti-Mouse CD20 Antibody (MB20-11) 是一种小鼠 IgG2c 抗体抑制剂，靶向 CD20。Anti-Mouse CD20 Antibody (MB20-11) 可消耗淋巴组织中的成熟 B 细胞。Anti-Mouse CD20 Antibody (MB20-11) 可用于癌症，免疫和代谢性疾病的研究，如淋巴瘤和糖尿病。

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Anti-Mouse CD20 Antibody (MB20-11)

Anti-Mouse CD20 Antibody (MB20-11) Chemical Structure

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Anti-Mouse CD20 Antibody (MB20-11) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes[1][2][3].

同型

Mouse IgG2c kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD20
体内研究
(In Vivo)

Anti-Mouse CD20 Antibody (MB20-11) (250 μg，静脉注射，单剂量) 可提高 BL3750 肿瘤模型小鼠的存活率[1]。
Anti-Mouse CD20 Antibody (MB20-11) (250 μg，单剂量) 可使野生型小鼠淋巴组织中 95% 以上的成熟 B 细胞耗竭，其作用可持续长达 8 周[2]。
Anti-Mouse CD20 Antibody (MB20-11) (250 μg，单剂量) 可抑制 BL3750 肿瘤小鼠模型中的肿瘤生长[2]。
Anti-Mouse CD20 Antibody (MB20-11) (250 μg，静脉注射，每 2 周 1 次，共 3 次) 可使非肥胖性糖尿病小鼠血液中 90% 和脾脏中 70% 的 B 细胞耗竭[3]。
Anti-Mouse CD20 Antibody (MB20-11) (250 μg，静脉注射，每 2 周 1 次，共 3 次) 可预防或延缓非肥胖性糖尿病小鼠中 1 型糖尿病的进展[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BL3750 tumor mice models[1]
Dosage: 250 μg
Administration: Intravenously injection
Result: Increased survival rate of mice.
Animal Model: BL3750 tumor mice models[2]
Dosage: 250 μg
Administration: /
Result: Suppressed tumor growth, with 89% of mice remaining disease free for 60 days or longer.
Reduced peritoneal B2 cell numbers.
Animal Model: Non-obese diabetic mice models[3]
Dosage: 250 μg
Administration: Intravenously injection, 3 times at 2-wk intervals
Result: Reduced circulating B cell numbers remained by 95%.
The majority of NOD mice remained diabetes free for up to 53 weeks.
Reduced the frequency of intrainsulitis and lymphocytes.
Significantly delayed diabetes onset when treated three times with CD20 mAb (weeks 15, 17, 19).
Reduces T cell proliferation.
基因 ID

12482  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD20 Antibody (MB20-11) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD20 Antibody (MB20-11)CD20B cellsCancerLymphomaBL3750DiabetesNODInhibitorinhibitorinhibit

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