2. Immunology/Inflammation
  3. CD28
  4. Anti-Mouse CD28 Antibody (D665)

Anti-Mouse CD28 Antibody (D665) 

目录号: HY-P990793
技术支持

Anti-Mouse CD28 Antibody (D665) 是一种小鼠来源的激动型 IgG1 κ 型抗体，靶向小鼠 CD28。Anti-Mouse CD28 Antibody (D665) 可诱导 T 细胞活化。Anti-Mouse CD28 Antibody (D665) 可用于神经系统疾病、炎症、免疫学和癌症等方面的研究，如帕金森病 (PD)、关节炎和移植物抗宿主病 (GVHD)。

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Anti-Mouse CD28 Antibody (D665)

Anti-Mouse CD28 Antibody (D665) Chemical Structure

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Anti-Mouse CD28 Antibody (D665) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD28 Antibody (D665) is a mouse-derived agonistic IgG1 κ type antibody, targeting to mouse CD28. Anti-Mouse CD28 Antibody (D665) induces the activation of T cells. Anti-Mouse CD28 Antibody (D665) can be used for the researches of neurological disease, inflammation, immunology and cancer, such as Parkinson disease (PD), arthritis and graft-versus-host disease (GVHD)[1][2][3][4].

同型

Mouse IgG1 kappa
反应种属

Mouse
IC50 & Target

CD28
体内研究
(In Vivo)

Anti-Mouse CD28 Antibody (D665) (200 μg，腹腔注射，第 7 天给药) 可减轻注射了 hαSyn 的帕金森病 (PD) 小鼠中的运动功能障碍，改善黑质多巴胺能细胞死亡，并抑制炎症[1]。
Anti-Mouse CD28 Antibody (D665) (100 μg，腹腔注射，第 7 天给药) 可减轻葡萄糖-6-磷酸异构酶 (G6PI) 诱导的关节炎小鼠的关节炎严重程度[2]。
Anti-Mouse CD28 Antibody (D665) (250 μg，腹腔注射，在分离脾脏 CD4+ 细胞前 3 天给药) 可预防移植了 C57BL/6 小鼠的 CD4+ 细胞的 BALB/c 小鼠中的移植物抗宿主病[3]。
Anti-Mouse CD28 Antibody (D665) (250 μg，腹腔注射，在从总脾细胞中分离 T 细胞前 3 天给药) 可延长 T 细胞转移的 BCL 淋巴瘤小鼠的生存期[3]。
Anti-Mouse CD28 Antibody (D665) (50 μg/mouse，腹腔注射，在 tMCAO 前 3 天给药) 可增加短暂性大脑中动脉闭塞 (tMCAO) 的模型小鼠中的调节性 T (Treg) 细胞数量，并加剧血栓炎症和缺血性神经变性[4] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HαSyn-injected PD mice[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, at days 7
Result: Increased Treg in cervical lymph nodes and spleen.
Showed a significant elevation of CD4+CD25+FoxP3+ Treg.
Revealed an expansion of Treg in brain.
Increased IL-10 levels in cervical lymph nodes and spleen.
Prolonged latency to fall from the rotarod.
Prevented the loss of dopaminergic and total Nissl+ neurons in the SN.
Reduced numbers of CD4+, CD8+ T cells and CD11b+ myeloid cells.
Animal Model: Glucose-6-phosphate isomerase (G6PI)-induced arthritis mice[2]
Dosage: 100 μg
Administration: Intraperitoneally injection, at days 7
Result: Reduced arthritis severity scores.
Showed no infiltration of neutrophils, macrophages or lymphocytes into the joints and cartilage destruction.
Increased CD4+CD25+Foxp3+ Treg cells.
Reduced the percentage of Th cells producing TNF-α, IL-17 or RANKL.
Increased Treg cells in both spleens and lymph nodes and levels of CTLA4 expression and proliferation.
基因 ID

12487  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD28 Antibody (D665) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD28 Antibody (D665)CD28T cellsParkinson diseaseArthritisGraft-versus-host diseaseInhibitorinhibitorinhibit

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