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  4. Anti-Mouse CD317/BST2 Antibody (927)

Anti-Mouse CD317/BST2 Antibody (927) 

目录号: HY-P990276
技术支持

Anti-Mouse CD317/BST2 Antibody (927) 是一种源自大鼠的 IgG2b κ 型抗体抑制剂，靶向小鼠 CD317/BST2。Anti-Mouse CD317/BST2 Antibody (927) 可消耗浆细胞样树突状细胞 (pDC)。Anti-Mouse CD317/BST2 Antibody (927) 可用于癌症、感染、炎症和免疫学的研究，如头颈部鳞状细胞癌 (HNSCC)、小鼠巨细胞病毒 (MCMV) 感染和哮喘。

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Anti-Mouse CD317/BST2 Antibody (927)

Anti-Mouse CD317/BST2 Antibody (927) Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse CD317/BST2 Antibody (927) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD317/BST2 Antibody (927) is a rat-derived IgG2b κ type antibody inhibitor, targeting to mouse CD317/BST2. Anti-Mouse CD317/BST2 Antibody (927) can deplete plasmacytoid dendritic cells (pDC). Anti-Mouse CD317/BST2 Antibody (927) can be used for the researches of cancer, infection, inflammation and immunology, such as head and neck squamous cell carcinoma (HNSCC), murine cytomegalovirus (MCMV) infection and asthma[1][2][3][4].

同型

Rat IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD317/BST2
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD317/BST2 Antibody (927) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD317/BST2 Antibody (927) (250 μg，腹腔注射，感染前 48 小时和 24 小时给药) 可减少小鼠巨细胞病毒 (MCMV) 感染的模型小鼠中的浆细胞样树突状细胞数量和血清 IFNα 水平[1]。
Anti-Mouse CD317/BST2 Antibody (927) (15 mg/kg，腹腔注射，隔日一次) 可有效清除浆细胞样树突状细胞，并抑制头颈部鳞状细胞癌 (HNSCC) 模型小鼠中的肿瘤生长[2]。
Anti-Mouse CD317/BST2 Antibody (927) (50 μg，静脉注射，从 HDM 激发前 1 小时开始，每周两次，共 5 周) 可减少浆细胞样树突状细胞，并促进屋尘螨 (HDM) 诱导的哮喘模型小鼠中的炎症反应[3]。
Anti-Mouse CD317/BST2 Antibody (927) (250 μg，腹腔注射，在第 7 天和第 8 天给药) 可改善实验性自身免疫性脑脊髓炎 (EAE) 模型小鼠中的 EAE 并缩短疾病持续时间[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Head and neck squamous cell carcinoma (HNSCC) mice models[2]
Dosage: 15 mg/kg
Administration: Intraperitoneally injection, every other day
Result: Decreased progression rate of tumor and proportion of plasmacytoid DC.
Decreased the tumor cell proliferative capacity.
Reduced the size of spleen and lymph nodes.
Increased the CD4+ and CD8+ T cell populations.
Downregulated PD-1, LAG-3 and TIM-3 expression on T cell subsets.
Reduced the population of Tregs and monocytic MDSCs.
Animal Model: House dust mite (HDM)-induced asthma mice models[3]
Dosage: 50 μg
Administration: Intravenously injection, twice a week for 5 weeks from 1 h before HDM
Result: Significantly reduced the percentages of plasmacytoid DC in the lungs.
Increased inflammatory cells, eosinophils, neutrophils, lymphocytes, and macrophages in the BAL fluid and lungs.
Increased the lung airway resistance and CD4+ cells, Th1, Th2, and Th17 cells.
Reduced Treg cells.
基因 ID

69550  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD317/BST2 Antibody (927) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD317/BST2 Antibody (927)Transmembrane GlycoproteinCD317BST2Plasmacytoid dendritic cellsHNSCCMCMVAsthmaHDMEAEInhibitorinhibitorinhibit

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