2. Apoptosis Immunology/Inflammation
  3. TNF Receptor IFNAR
  4. Anti-Mouse CD40L/CD154 Antibody (MR-1)

Anti-Mouse CD40L/CD154 Antibody (MR-1) 

目录号: HY-P990134 纯度: 99.62%
COA 技术支持

Anti-Mouse CD40L/CD154 Antibody (MR-1) 是一种抗小鼠 CD40L/CD154 IgG 单克隆抗体。Anti-Mouse CD40L/CD154 Antibody (MR-1) 降低 IFN 信号通路的表达并降低 IFN-β 水平。Anti-Mouse CD40L/CD154 Antibody (MR-1) 可以延长移植的存活时间。Anti-Mouse CD40L/CD154 Antibody (MR-1) 可用于癌症，炎症疾病和异种移植如胰腺癌，自身免疫性胆管炎的研究。

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Anti-Mouse CD40L/CD154 Antibody (MR-1)

Anti-Mouse CD40L/CD154 Antibody (MR-1) Chemical Structure

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3.  试用装只面向终端客户。

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5 mg ￥3600
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Anti-Mouse CD40L/CD154 Antibody (MR-1) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis[1][2][3].

同型

Armenian hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD40L/CD154
体外研究
(In Vitro)

Anti-Mouse CD40L/CD154 Antibody (MR-1) (200 μg/mL，48 小时) 显著抑制自然杀伤 T (NKT) 细胞中 IFN-β 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD40L/CD154 Antibody (MR-1) 相关抗体:

ELISA Assay[1]

Cell Line: NKT cells, co-cultivation with peritoneal macrophages
Concentration: 200 μg/mL
Incubation Time: 48 h
Result: Reduced the level of IFN-β.
体内研究
(In Vivo)

Anti-Mouse CD40L/CD154 Antibody (MR-1) (500 μg，腹腔注射，每 2 天一次，从肿瘤接种前 2 天到接种后 12 天) 显著降低了携带 KPC1242 肿瘤的雄性 C57BL/6J 小鼠中 I 型 IFN 信号通路相关基因的表达[1]。
Anti-Mouse CD40L/CD154 Antibody (MR-1) (20 mg/kg，腹腔注射，在手术前 1 天每天一次持续 4 天，之后每周一次直到实验结束) 延长了 5XFAD 转基因小鼠中人类神经干细胞 (hNSCs) 的存活时间[2]。
Anti-Mouse CD40L/CD154 Antibody (MR-1) (25 mg/kg，腹腔注射，初始阶段为第 0、2、4 和 7 天，维持阶段为每周一次) 可以暂时延缓 dnTGFβRII 小鼠胆管炎的进展[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×104 KPC1242 cells injected male C57BL/6J mice (8-12 weeks)[1]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation
Result: Significantly reduced the expression of IFN signaling pathway.
Animal Model: 5XFAD transgenic mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 days at 1 day before surgery, once a week until the end of the experiment
Result: Extended the survival time of hNSCs to 34 weeks.
Significantly suppressed transplant rejection reaction.
Animal Model: dnTGFβRII mice (3-4 weeks)[3]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage
Result: Significantly reduced portal vein inflammation and bile duct injury scores for short-term treatment.
Reduced intrahepatic NKT cells and effector T cells in short-term treatment.
Reduced the levels of IFN-γ, IL-4 and IL-17A for short-term treatment.
基因 ID

21947  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.62%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD40L/CD154 Antibody (MR-1) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40L/CD154 Antibody (MR-1)TNF ReceptorIFNARTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorCD40L/CD154IFNtransplantsKPC1242Inhibitorinhibitorinhibit

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