2. Immunology/Inflammation Anti-infection
  3. Transmembrane Glycoprotein Orthopoxvirus
  4. Anti-Mouse CD69 Antibody (CD69.2.2)

Anti-Mouse CD69 Antibody (CD69.2.2) 

目录号: HY-P990265
技术支持

Anti-Mouse CD69 Antibody (CD69.2.2) 是一种小鼠来源的 IgG1 κ 型抗体抑制剂，靶向小鼠 CD69。Anti-Mouse CD69 Antibody (CD69.2.2) 可使 CD69 内化，但不会耗竭 CD69+ 细胞。Anti-Mouse CD69 Antibody (CD69.2.2) 可用于癌症、感染、炎症和免疫学等方面的研究，如 RMA-S 肿瘤、关节炎和痘苗病毒 (VACV) 感染。

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Anti-Mouse CD69 Antibody (CD69.2.2)

Anti-Mouse CD69 Antibody (CD69.2.2) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Mouse CD69 Antibody (CD69.2.2) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD69 Antibody (CD69.2.2) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD69. Anti-Mouse CD69 Antibody (CD69.2.2) causes CD69 to be internalized but does not deplete CD69+ cells. Anti-Mouse CD69 Antibody (CD69.2.2) can be used for the researches of cancer, infection, inflammation and immunology, such as RMA-S tumor, arthritis and vaccinia virus (VACV) infection[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD69
体外研究
(In Vitro)

Anti-Mouse CD69 Antibody (CD69.2.2) (10 μg/mL, 1 h) 在 37℃ 时易于在 CD69+ 细胞中内化[1]。
Anti-Mouse CD69 Antibody (CD69.2.2) (10 μg/mL, 18 h) 可增加脾细胞中 NK 细胞的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD69 Antibody (CD69.2.2) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg，腹腔注射，在第 -1 天或第 1 天给药) 导致 RMA-S 肿瘤模型小鼠中，8 周后超过 80% 的小鼠存活且无肿瘤[1]。
Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg，腹腔注射，在第 1 天和第 5 天给药) 可减少 RM-1 肿瘤模型小鼠中的肿瘤转移并延长生存期[1]。
Anti-Mouse CD69 Antibody (CD69.2.2) (200 μg，腹腔注射，单剂量) 在 RMA-S/RM-1/YAC-1 肿瘤模型小鼠中持续且显著地增强自然杀伤细胞依赖性细胞毒活性[1]。
Anti-Mouse CD69 Antibody (CD69.2.2) (300 μg，腹腔注射，在第 1 天和第 5 天给药) 可下调胶原抗体诱导的关节炎模型小鼠中 CD69 的表达，且不影响疾病严重程度[2]。
Anti-Mouse CD69 Antibody (CD69.2.2) (500 μg，静脉注射，感染前 24 小时给药) 可增强牛痘病毒 (VACV) 感染的模型小鼠中的先天免疫反应[3]。
Anti-Mouse CD69 Antibody (CD69.2.2) (200 μg，静脉注射，每周两次) 对牛痘病毒 (VACV) 感染的 Rag2-/- 小鼠具有抗感染作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: RM-1 tumor mice models[1]
Dosage: 500 μg
Administration: Intraperitoneally injection, at days 1 and 5
Result: Drastically reduced tumor metastasis.
Increased survival rate of mice.
Animal Model: Vaccinia virus (VACV)-infected mice models[3]
Dosage: 500 μg
Administration: Intraperitoneally injection, 24 h before infection
Result: Showed slightly lower ovarian viral titers.
Increased the numbers of TNF-α-producing NK, CD8+ T, and CD4+ T cells and IFN-γ-producing NK and CD4+ T cells.
基因 ID

12515  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse CD69 Antibody (CD69.2.2) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD69 Antibody (CD69.2.2)Transmembrane GlycoproteinOrthopoxvirusCD69NK cellsCancerRMA-SRM-1YAC-1ArthritisVaccinia virusInhibitorinhibitorinhibit

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