2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD8 Antibody (HB-129)

Anti-Mouse CD8 Antibody (HB-129) 

目录号: HY-P990262 纯度: 95.00%
COA 技术支持

Anti-Mouse CD8 Antibody (HB-129) 是一种源自小鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 CD8。Anti-Mouse CD8 Antibody (HB-129) 可消耗 CD8+ T 细胞。Anti-Mouse CD8 Antibody (HB-129) 可用于癌症、炎症、免疫学和代谢性疾病的研究，如 P815 肿瘤、实验性自身免疫性甲状腺炎 (EAT) 和移植物抗宿主病 (GVHD)。

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Anti-Mouse CD8 Antibody (HB-129)

Anti-Mouse CD8 Antibody (HB-129) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥4200
In-stock
5 mg   询价  
10 mg   询价  

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Anti-Mouse CD8 Antibody (HB-129) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8+ T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD)[1][2][3].

同型

Mouse IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD8
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD8 Antibody (HB-129) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD8 Antibody (HB-129) (200 μg，腹腔注射，从第 8 天起每周一次) 会降低 Dasatinib (HY-10181) 在 P815 肿瘤小鼠模型中的抗肿瘤反应[1]。
Anti-Mouse CD8 Antibody (HB-129) (腹腔注射，在第 1 天和第 12 天以及此后每 10 天一次给药) 会略微加重肉芽肿性实验性自身免疫性甲状腺炎 (EAT) 的严重程度，并抑制其在实验性自身免疫性甲状腺炎模型小鼠中的消退[2]。
Anti-Mouse CD8 Antibody (HB-129) (5 μg/g，转移前 5 天给药) 可预防造血细胞移植的 NOD 小鼠发生移植物抗宿主病 (GVHD)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P815 tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, once a week from day 8
Result: Reduced anti-tumor responses of Dasatinib (HY-10181), with big tumor size and short survival.
Animal Model: Experimental autoimmune thyroiditis (EAT) mice models[2]
Dosage: /
Administration: Intraperitoneally injection, at days 1 and 12 and at 10-day intervals thereafter
Result: Developed 4-5+ granulomatous EAT 21 days after cell transfer.
Persisted infiltration at both 35 and 48 days after cell transfer.
Reduced CD8 mRNA levels.
Unaffected or increased IFN-α, IL-2, IL-4, and IL-10 mRNA levels.
基因 ID

12525  [NCBI]

Accession

P01731-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD8 Antibody (HB-129) 相关分类

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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD8 Antibody (HB-129)Transmembrane GlycoproteinCD8T cellsP815CancerExperimental autoimmune thyroiditisGraft versus host diseaseDiabetesInhibitorinhibitorinhibit

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