2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD96 Antibody (3.3)

Anti-Mouse CD96 Antibody (3.3) 

目录号: HY-P990259 纯度: 95.00%
COA 技术支持

Anti-Mouse CD96 Antibody (3.3) 是一种源自大鼠的抗小鼠 CD96 IgG1 λ 型抗体抑制剂。Anti-Mouse CD96 Antibody (3.3) 可阻断 CD155 与 CD96 的结合。Anti-Mouse CD96 Antibody (3.3) 可增强多种免疫检查点抑制剂的抗肿瘤功效。Anti-Mouse CD96 Antibody (3.3) 在多种肿瘤模型中显示出强大的抗肿瘤和抗转移活性。Anti-Mouse CD96 Antibody (3.3) 可用于癌症和炎症的研究，如乳腺癌。

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Anti-Mouse CD96 Antibody (3.3)

Anti-Mouse CD96 Antibody (3.3) Chemical Structure

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1 mg ￥1800
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Anti-Mouse CD96 Antibody (3.3) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma[1][2][3][4].

同型

Rat IgG1 lambda
反应种属

Mouse
IC50 & Target

CD96
体外研究
(In Vitro)

Anti-Mouse CD96 Antibody (3.3) (0.0001-100 μg/mL, 48 h) 可剂量依赖性地降低 HEK-293 细胞中 CD155 与 CD96 的结合[1]。
Anti-Mouse CD96 Antibody (3.3) (24 h) 可增强 PD-1 阻断作用，从而在肿瘤单细胞中释放 CD8 阳性肿瘤浸润淋巴细胞的功能[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD96 Antibody (3.3) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CD96 Antibody (3.3) (250-400 μg，腹腔注射，给药 2 次) 在 B16F10 实验性转移瘤和原位 4T1.2 乳腺癌小鼠模型中显示出显著的抗转移活性[1]。
Anti-Mouse CD96 Antibody (3.3) (250 μg，腹腔注射，给药 4 次) 在 B16F10/CT26/MCA1956 肿瘤模型中显示出强大的抗肿瘤作用[2]。
Anti-Mouse CD96 Antibody (3.3) (200 μg，腹腔注射，每周 2 次) 显著延缓 TC-1 肿瘤负荷小鼠模型中的肿瘤生长并延长小鼠的生存期[3]。
Anti-Mouse CD96 Antibody (3.3) (250 μg，腹腔注射) 在同种异体皮肤移植的 CD96high 小鼠模型中能恢复 Th9 细胞的炎症特性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 experimental metastases mice models[1]
Dosage: 250 μg
Administration: Intraperitoneally injection, at day 0, 3
Result: Had significant anti-metastatic activity.
Mediated metastases suppression via NK cells and IFN-γ.
Animal Model: Orthotopic 4T1.2 mammary carcinoma mice models[1]
Dosage: 400 μg
Administration: Intraperitoneally injection, at day 12, 14
Result: Displayed significant anti-metastatic activity.
Animal Model: B16F10/CT26/MCA1956 tumor models[2]
Dosage: 250 μg
Administration: Intraperitoneally injection, for 4 times
Result: Suppressed tumor growth
Enhanced the antitumor efficacy of multiple immune-checkpoint inhibitors.
Animal Model: TC-1 tumor-bearing C57BL/6 mice models[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, 2 times a week
Result: Significantly delayed tumor growth and prolonged the survival.
Animal Model: Allogeneic skin transplantation CD96high mice models[4]
Dosage: 250 μg
Administration: Intraperitoneally injection
Result: Enhanced skin graft inflammation.
Displayed more severe destruction and T-cell infiltration.
Significantly increased T-cell numbers in draining and mesenteric lymph nodes and in the spleen.
基因 ID

84544  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD96 Antibody (3.3) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD96 Antibody (3.3)Transmembrane GlycoproteinCD96CD155CancerInflammationMammary carcinoma4T1 cellsB16F10 cellsCT26 cellsMCA1956 cellsInhibitorinhibitorinhibit

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