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  4. Anti-Mouse DKK3 Antibody (DKK3-4.22)

Anti-Mouse DKK3 Antibody (DKK3-4.22) 

目录号: HY-P990250 纯度: 95.00%
COA 技术支持

Anti-Mouse DKK3 Antibody (DKK3-4.22) 是一种抗小鼠 DKK3 IgG1 单克隆抗体。Anti-Mouse DKK3 Antibody (DKK3-4.22) 可以改善肾功能并增加 T 细胞浸润。Anti-Mouse DKK3 Antibody (DKK3-4.22) 可以通过阻断 DKK3 的免疫抑制功能来减轻皮肤炎症。Anti-Mouse DKK3 Antibody (DKK3-4.22) 可用于研究炎症疾病，如单侧输尿管梗阻 (UUO) 和实验性自身免疫性脑脊髓炎 (EAE)。

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Anti-Mouse DKK3 Antibody (DKK3-4.22)

Anti-Mouse DKK3 Antibody (DKK3-4.22) Chemical Structure

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Anti-Mouse DKK3 Antibody (DKK3-4.22) 相关抗体

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  • 生物活性

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生物活性

Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse DKK3 IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE)[1][2].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

DKK3
体内研究
(In Vivo)

Anti-Mouse DKK3 Antibody (DKK3-4.22) (0.5-1 mg，腹腔注射，每 3 天一次，持续 21 天) 改善单侧输尿管梗阻 (UUO) 雄性 C57BL/6 小鼠的肾功能并增加 T 细胞浸润[1]。
Anti-Mouse DKK3 Antibody (DKK3-4.22) (500 μg，腹腔注射，每周一次，共 3 次) 可以阻断具有实验性自身免疫性脑脊髓炎 (EAE) 转基因 Ker-MBP 小鼠体内 DKK3 的免疫抑制功能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice with an UUO model (8-12 weeks)[1]
Dosage: Initial dose 1 mg, followed by 0.5 mg
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 21 days
Result: Significantly reduced renal tubular atrophy and interstitial fibrosis.
Increased the infiltration of T cells in the kidneys.
Animal Model: MBP peptide segment (200 μg) and pertussis toxin (200 ng) induced transgenic Ker-MBP mice[2]
Dosage: 500 μg, pretreated with diphenylcycloprenone (DPCP) ( Initial dose 2 % solution followed by 0.1-0.5 % solution, once weekly, for 4 times)
Administration: Intraperitoneal injection (i.p.), once weekly for 3 times
Result: Eliminated the alleviating effect of DPCP on EAE symptoms.
基因 ID

50781  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse DKK3 Antibody (DKK3-4.22) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse DKK3 Antibody (DKK3-4.22)WntDKK3T cellUUOEAEInhibitorinhibitorinhibit

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