2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. Anti-Mouse GM-CSF Antibody (MP1-22E9)

Anti-Mouse GM-CSF Antibody (MP1-22E9) 

目录号: HY-P99134 纯度: 95.00%
COA 技术支持

Anti-Mouse GM-CSF Antibody (MP1-22E9) 是一种源自大鼠的抗小鼠 GM-CSF IgG2a 抗体抑制剂。Anti-Mouse GM-CSF Antibody (MP1-22E9) 可中和 GM-CSF。Anti-Mouse GM-CSF Antibody (MP1-22E9) 可用于癌症、感染、炎症和免疫学研究，如胆管癌和关节炎。

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Anti-Mouse GM-CSF Antibody (MP1-22E9)

Anti-Mouse GM-CSF Antibody (MP1-22E9) Chemical Structure

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Anti-Mouse GM-CSF Antibody (MP1-22E9) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse GM-CSF Antibody (MP1-22E9) is a rat-derived anti-mouse GM-CSF IgG2a antibody inhibitor. Anti-Mouse GM-CSF Antibody (MP1-22E9) can neutralize GM-CSF. Anti-Mouse GM-CSF Antibody (MP1-22E9) can be used for the researches of cancer, infection inflammation and immunology, such as cholangiocarcinoma and arthritis[1][2][3][4][5][6].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

GM-CSF
体外研究
(In Vitro)

Anti-Mouse GM-CSF Antibody (MP1-22E9) (72 h) 显著降低骨髓来源巨噬细胞中的巨噬细胞活力[1]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (10 μg/mL, 30 mins) 促进骨髓来源抑制性细胞的分化和迁移[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse GM-CSF Antibody (MP1-22E9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse GM-CSF Antibody (MP1-22E9) (30 mg/kg，腹腔注射，每 2 天一次，持续 4 周) 可抑制自发性肝内胆管癌小鼠模型中肿瘤的进展并延长生存期[1]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (800 μg，腹腔注射，每周一和周四一次，持续 2 周) 可减少 L2/IKKβca 小鼠的血管生成[2]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (250 μg，腹腔注射，在注射凝胶多糖前一天给药，之后每周两次，持续 7 周；或在疾病诱发后 9 天给药，之后每周两次，直至第 28 天) 可抑制脊柱关节炎小鼠模型中的骨髓髓系造血和器官炎症[3]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (200 μg，腹腔注射，每 3 天一次) 可通过中和 GM-CSF 抑制 B16F10-OVA 荷瘤模型小鼠中的抗肿瘤免疫[4]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (100 μg，腹腔注射，每周两次) 在 HM-1 肿瘤模型小鼠中显示出抗肿瘤作用[5]。
Anti-Mouse GM-CSF Antibody (MP1-22E9) (250 μg，腹腔注射，感染前一天开始，每隔一天一次，共 3 次) 在艰难梭菌感染的小鼠模型中显示出抗感染作用[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Autochthonous intrahepatic cholangiocarcinoma mice models[1]
Dosage: 30 mg/kg
Administration: Intraperitoneally injection, every 2days for 4 weeks
Result: Suppressed tumor growth and increased latency to the development of multifocal liver tumours.
Significant reduced TAM infiltration and expression of ARG1 and PD-L1.
Significantly reduced circulating monocytes in the blood and elevated numbers of BM granulocytes.
Significantly reduced CFU in BM mononuclear cells and splenocytes.
Animal Model: L2/IKKβca mice[2]
Dosage: 800 μg
Administration: Intraperitoneally injection, every monday and thursday for 2 weeks
Result: Reduced the number of CD31+ blood vessels and VWF positive endothelial cells.
Animal Model: Spondyloarthritis mice models[3]
Dosage: 250 μg
Administration: Intraperitoneally injection, at the day before curdlan injection and twice weekly for 7 weeks or 9 days after disease triggering and twice weekly until day 28
Result: Decreased in LT-HSCs, MPPs and GMPs in the BM and increased CLPs cells.
Reducecd neutrophils and increased erythroid cells and B cells.
Decreased intestinal and articular neutrophil invasion.
Showed significant ameliorations in the histological and clinical scores of arthritis, marked decreases in enthesitis-associated ankle thickening and new bone formation, and inhibition of the bone surface:volume ratio increase.
Showed significant amelioration in enteritis and weight loss.
Animal Model: B16F10-OVA tumor-bearing mice models[4]
Dosage: 200 μg
Administration: Intraperitoneally injection, every 3 days
Result: Reduced the IL9-inducing capacity of moDCs and cDCs.
Increased or unaffected s IFNγ induction from naive or total CD4+ T cells.
Animal Model: HM-1 tumor mice models[5]
Dosage: 100 μg/mouse
Administration: Intraperitoneally injection, twice a week
Result: Suppressed tumor growth.
Decreased MDSCs.
Enhanced the efficacy of anti-VEGF abs.
Animal Model: Clostridium difficile infected mice models[6]
Dosage: 250 μg/mouse
Administration: Intraperitoneally injection, every other day beginning one day prior to infection for 3 times
Result: Showed lower C. difficile colonization levels and more modest weight loss.
Reduced IL-22 levels.
Resulted in significantly lower expression of IL-1β and TNFα.
Significantly reduced expression of the ELR+ CXC chemokines CXCL1 (KC) and CXCL2 (MIP-2).
Reduced neutrophils t in colonic mucosal sections and decreased iNOS expression.
基因 ID

12981  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse GM-CSF Antibody (MP1-22E9) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse GM-CSF Antibody (MP1-22E9)c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RGM-CSFCancerCholangiocarcinomaArthritisB16F10-OVAHM-1Clostridium difficileInhibitorinhibitorinhibit

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