2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse/Rat IL-17A Antibody (17F3)

Anti-Mouse/Rat IL-17A Antibody (17F3) 

目录号: HY-P990222 纯度: 99.04%
COA 技术支持

Anti-Mouse IL-17A Antibody (17F3) 是一种源自小鼠的 IgG1 κ 型抗体抑制剂，靶向小鼠 IL-17A。Anti-Mouse IL-17A Antibody (17F3) 可中和 IL-17。Anti-Mouse IL-17A Antibody (17F3) 可用于感染、免疫和代谢性疾病的研究，如胞内分枝杆菌感染和糖尿病。

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Anti-Mouse/Rat IL-17A Antibody (17F3) 相关抗体

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-17A Antibody (17F3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IL-17A
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat IL-17A Antibody (17F3) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-17A Antibody (17F3) (100 μg，腹腔注射，两天一次，持续 11 天) 在胞内分枝杆菌感染的小鼠模型中显示出强大的抗感染效果[1]。
Anti-Mouse IL-17A Antibody (17F3) (0.5 mg/dose，腹腔注射，每周 3 次) 可减少免疫检查点抑制剂 (ICI) 治疗的小鼠模型中的自身免疫浸润[2]。
Anti-Mouse IL-17A Antibody (17F3) (200 μg，腹腔注射，每周两次，直至第 12 周) 对链脲佐菌素 (HY-13753) 诱导的糖尿病小鼠的糖尿病肾病具有保护作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: M.intracellulare-infected mice models (C57BL/6, female, 6-8 weeks)[1]
Dosage: 100 μg
Administration: Intraperitoneally injection, every other day for 11 days
Result: Reduced IL-17A levels and increased IL-4 and IL-22 levels.
Decreased the date rate of infectious mice.
Reduced bacteria.
Significantly reduced subsequent granulomatous and fibrotic changes in the lungs.
Increased the number of DCs and NK cells in the lungs.
Reduced MMP-3 production.
基因 ID

16171  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized IL-17A Protein, Mouse (HEK293, His, HY-P70753) can bind Anti-Mouse IL-17A Antibody (17F3). The EC50 for this effect is 13 ng/mL.
纯度 & 产品资料

纯度: 99.04%

COA (267 KB) SDS-PAGE (232 KB) SEC-HPLC (315 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse/Rat IL-17A Antibody (17F3) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat IL-17A Antibody (17F3)Interleukin RelatedILIL-17M.intracellulareInfectionDiabetesInhibitorinhibitorinhibit

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产品名称：
Anti-Mouse/Rat IL-17A Antibody (17F3)
目录号：
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