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  2. Il17a - interleukin 17A Gene

Il17a - interleukin 17A Gene

中文名称:白细胞介素 17A

种属: Mus musculus

同用名: Il17; Ctla8; IL-17; Ctla-8; IL-17A

基因 ID: 16171 | 基因类型: protein coding

关于 Il17a

Chromosome 1: 20,801,129-20,804,720 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 97 orthologues, 5 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.


该基因编码一种促炎细胞因子,它是白细胞介素 17 家族的一员。编码的蛋白质在宿主防御多种病原体中起着核心作用。编码的蛋白质由活化的 T 细胞和先天免疫系统的某些细胞类型产生。活性蛋白作为与其他白细胞介素 17 家族成员的同型二聚体发挥作用,并通过白细胞介素 17 受体发出信号以诱导炎性细胞因子的产生。该基因的异常表达与自身炎症性疾病有关,包括类风湿性关节炎、牛皮癣和多发性硬化症。 [RefSeq 提供,2015 年 9 月]

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Il17a 基因产物(1)

mRNA Protein Name
NM_010552.3 NP_034682.1 interleukin-17A precursor

Il17a 蛋白结构


IL17: pfam06083 (71 - 149)

  • 0
  • 100
  • 158 a.a.
蛋白主名 其他名称


cytotoxic T-lymphocyte-associated antigen 8

重组 Il17a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7372 IL-17A Protein, Mouse (CHO) Q62386 (A26-A158) ≥95%
HY-P70753 IL-17A Protein, Mouse (HEK293, His) Q62386 (T22-A158) ≥95%
HY-P73174 IL-17A Protein, Mouse Q62386 (T22-A158) ≥95%
HY-P77707 IL-17A-17F Heterodimer Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7 (R29-A161) ≥95%
HY-P77708 IL-17A-17F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158)&Q7TNI7-1 (R29-A161) ≥95%
HY-P78158 IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62386 (A26-A158) ≥95%
HY-P78320 IL-17A Protein, Mouse (HEK293, His-Avi) Q62386 (A26-A158) ≥95%
HY-P700194AF Animal-Free IL-17A Protein, Mouse (His) Q62386 (A26-A158) ≥95%


种属 基因名 来源 基因 ID
Homo sapiens Il17a NCBI NCBI:3605
Canis familiaris Il17a NCBI NCBI:481837
Macaca fascicularis Il17a NCBI NCBI:102119976
Susscrofa domestica Il17a NCBI
Leporidae Il17a NCBI
Rattus norvegicus Il17a NCBI NCBI:301289
Macaca mulatta Il17a NCBI NCBI:708123