2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-1a Antibody (ALF-161)

Anti-Mouse IL-1a Antibody (ALF-161) 

目录号: HY-P99138 纯度: ≥95.0%
COA 技术支持

Anti-Mouse IL-1a Antibody (ALF-161) 是一种抗小鼠 IL-1a IgG1 单克隆抗体。Anti-Mouse IL-1a Antibody (ALF-161) 可以通过阻断 IL-1a 信号传导来抑制 CD8+ T 细胞反应。Anti-Mouse IL-1a Antibody (ALF-161) 可以逆转髓系细胞扩增并改善 T 细胞功能。Anti-Mouse IL-1a Antibody (ALF-161) 可用于免疫应答和癌症如乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Anti-Mouse IL-1a Antibody (ALF-161)

Anti-Mouse IL-1a Antibody (ALF-161) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1800
In-stock
5 mg 现货 询价
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Anti-Mouse IL-1a Antibody (ALF-161) 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for researches on immune response and cancer such as breast cancer[1][2].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][2]

IL-1α

 

体内研究
(In Vivo)

Anti-Mouse IL-1a Antibody (200 μg，腹腔注射，每周两次，持续 4 周) 可以抑制注射腺相关病毒卵清蛋白 (AAV-OVA) 的 C57BL/6J 小鼠的 CD8+ T 细胞反应[1]。
Anti-Mouse IL-1a Antibody (200 µg，腹腔注射，每 3 天一次，直到实验结束) 可以逆转携带 AT3 肿瘤的野生型雌性 C57BL/6 小鼠的髓系细胞扩增并改善 T 细胞功能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×109 vg AAV-OVA injected C57BL/6J mice (6-8 weeks)[1]
Dosage: 200 μg, combined with IL-1b mAb (HY-P99139) (200 μg)
Administration: Intraperitoneal injection (i.p.), twice weekly, for 4 weeks
Result: Reduced the response rate from 67 % to 33 % and lowered the frequency by about three times when used alone.
Further reduced the response rate to 19 %-20 % when combined with IL-1b mAb.
Slightly reduced anti OVA IgG2c but did not affect anti capsid antibodies.
Animal Model: 5×105 AT3 cells injected wild-type female C57BL/6 mice (8-10 weeks)[2]
Dosage: 200 μg, combined with IL-1R mAb (HY-P99140) (200 μg)
Administration: Intraperitoneal injection (i.p.), once every 3 days until the end of the experiment
Result: Significantly reduced the expansion of neutrophils and immature CD11b+ myeloid cells in the spleen.
Prevented a decrease in T cell subpopulations, such as initial and central memory CD8+ T cells.
Reduced circulating G-CSF levels.
Effectively restored APC function and T cell response when combined with IL-1R mAb.
基因 ID

16175  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-1a Antibody (ALF-161) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1a Antibody (ALF-161)Interleukin RelatedILIL-1aCD8T cellImmunologyAT3breast cancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Anti-Mouse IL-1a Antibody (ALF-161)
目录号：
HY-P99138
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z