2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-1R Antibody (JAMA-147)

Anti-Mouse IL-1R Antibody (JAMA-147) 

目录号: HY-P99140 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-1R Antibody (JAMA-147) 是一种源自亚美尼亚仓鼠宿主的抗小鼠 IL-1R IgG2b 抗体抑制剂。Anti-Mouse IL-1R Antibody (JAMA-147) 可减弱 Spp1 高表达肿瘤相关巨噬细胞 (Spp1hi-TAM) 介导的 T 细胞抑制作用。Anti-Mouse IL-1R Antibody (JAMA-147) 可用于炎症、代谢疾病和感染等方面的研究，如糖尿病。

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Anti-Mouse IL-1R Antibody (JAMA-147)

Anti-Mouse IL-1R Antibody (JAMA-147) Chemical Structure

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Anti-Mouse IL-1R Antibody (JAMA-147) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes[1][2][3][4].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IL-1

 

体外研究
(In Vitro)

Anti-Mouse IL-1R Antibody (JAMA-147) (10 μg/mL, 3 days) 可显著减轻 CD8 阳性 T 细胞中 Spp1 高表达肿瘤相关巨噬细胞 (Spp1hi-TAM) 介导的 T 细胞抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-1R Antibody (JAMA-147) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-1R Antibody (JAMA-147) (200 µg/dose，腹腔注射，从第 14 到 28 天，每 3 天 1 次) 降低了实验性自身免疫性前列腺炎 (EAP) 小鼠模型中 IL-17+ 调节性 T 细胞比例，并缓解了 Th17/Treg 比例的失衡[1]。
Anti-Mouse IL-1R Antibody (JAMA-147) (50 μg/kg，腹腔注射，每天 1 次，持续 4 周) 可改善 8-10 周龄晚期糖尿病前期非肥胖糖尿病 (NOD) 小鼠模型中的 I 型干扰素受体 (IFNAR) 信号传导[3]。
Anti-Mouse IL-1R Antibody (JAMA-147) (40 mg/kg，腹腔注射) 可增强新生脑膜炎致病性大肠杆菌 (NMEC) RS218 在诱导型一氧化氮合酶 2 基因敲除 (NOS2-/-) 小鼠大脑、血液及其他组织中的定植[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental autoimmune prostatitis (EAP) mice models (NOD, male, 5 weeks)[1]
Dosage: 200 µg/dose
Administration: Intraperitoneally injection, every 3 days from day 14 to 28
Result: Decreased T17 cells and 17+Treg cells and increased Treg cells.
Animal Model: NOD (non-obese diabetic) mice models (female, 8-10 weeks)[3]
Dosage: 50 μg/kg
Administration: Intraperitoneally injection, daily for 4 weeks
Result: Increased expression of tonic-sensitive Irf7, Ifit1, Mx1, Stat1, and Stat2 in the spleen.
基因 ID

16177  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse IL-1R Antibody (JAMA-147) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1R Antibody (JAMA-147)Interleukin RelatedILIL-1Spp1hi-TAMT cellinflammationdiabetesEAPNMEC RS218Inhibitorinhibitorinhibit

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