2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 

目录号: HY-P990209 纯度: 95.00%
COA 技术支持

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 IL-7Rα/CD127。Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 可阻断 IL-7 信号传导。Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 可用于癌症、感染、炎症、免疫学、心血管和代谢性疾病等研究，如腹主动脉瘤、幽门螺杆菌诱导的胃炎和糖尿病。

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Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) Chemical Structure

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Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-7Rα/CD127. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) blocks IL-7 signaling. Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) can be used for the researches of cancer,infection, inflammation, immunology, cardiovascular and metabolic disease, such as abdominal aortic aneurysms, helicobacter felis-induced gastritis and diabetes[1][2][3][4][5].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IL-7Rα/CD127
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) (20 μg/mouse，腹腔注射，从第 2 天到第 14 天每天给药) 可延缓弹性蛋白酶 (HY-P2974) 诱导的小鼠腹主动脉瘤进展[1]。
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) (预防治疗：每周 2 次，每次 250 μg，持续 6-8 周；逆转治疗：在第 5-7 周开始，每周 2 次，每次 500 μg，腹腔注射) 可预防和逆转 C3H/HeJ 皮肤移植斑秃小鼠模型中的斑秃[2]。
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) (5 mg，腹腔注射，每七天一次，持续 3 个月) 可抑制幽门螺杆菌诱导的胃炎小鼠模型中胃炎的发展[3]。
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) (第一周 500 μg，随后 6 周每周 125 μg，腹腔注射，每周两次) 可减轻载脂蛋白 E 基因敲除小鼠心肌梗死后诱导的动脉粥样硬化斑块炎症[3]。
Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) (0.5 mg，腹腔注射，每周两次，持续 5-14 周) 可预防和逆转非肥胖糖尿病小鼠模型中的糖尿病[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Abdominal aortic aneurysms mice models[1]
Dosage: 20 μg/mouse
Administration: Intraperitoneally injection, daily from day 2 to 14, companied with Elastase (HY-P2974)
Result: Significantly suppressed the expansion of the abdominal aorta.
Significantly decreased the proportion of infiltrating macrophages.
Animal Model: C3H/HeJ skin-grafted mice models of alopecia areata[2]
Dosage: 250 μg twice a week for 6-8 weeks for prevention treatment, 500 μg twice a week for 8 weeks from 5 to 7 week for reversal treatment
Administration: Intraperitoneally injection
Result: Did not displad any signs of hair loss with prevention treatment.
Markedly inhibited 1MOG244 CD8+ T cell proliferation with prevention treatment.
Showed more than 60% of treated mice displayed hair regrowth in areas of previous hair loss with reversal treatment.
Substantially reduced skin inflammation and the frequency of CD45+ immune infiltrates with reversal treatment.
Inhibited T effector cell function and favored immune regulation.
Animal Model: Helicobacter felis-induced gastritis mice models[3]
Dosage: 5 mg
Administration: Intraperitoneally injection, every seventh day for 3 months
Result: Had no gastritis and low scores for chronic inflammation, atrophic changes, and mucosal hyperplasia.
Showed low proportion of Thy-1-positive cells.
Inhibited regulation of IL-1α, TNF-α, IL-7R, and IFN-γ.
Animal Model: Myocardial infarction in ApoE-/-mice models[4]
Dosage: 500 μg at the first week and 125 μg until 6 weeks post-MI
Administration: Intraperitoneally injection, twice a week
Result: Displayed significant reduction in lipid and macrophage content.
Animal Model: Non-obese diabetic mice models[5]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, twice a week for 14 weeks, starting at 10 week of age
Result: Only 10% of mice developed diabetes.
Reducesd islet infiltration.
Animal Model: Non-obese diabetic mice models[5]
Dosage: 0.5 mg
Administration: Intraperitoneally injection, twice a week for 4 week
Result: Restored normoglycemia of 50%.
Increased cell-intrinsic and cell-extrinsic inhibition of CD4+ T Cells.
基因 ID

16197  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (269 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-7Rα/CD127 Antibody (A7R34)Interleukin RelatedILIL-7RαCD127IL-7Abdominal aortic aneurysmsHelicobacter felisGastritisDiabetesMyocardial infarctionAlopecia areataInhibitorinhibitorinhibit

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