2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Anti-Mouse OX40/CD134 Antibody (OX-86)

Anti-Mouse OX40/CD134 Antibody (OX-86) 

目录号: HY-P990115
技术支持

Anti-Mouse OX40/CD134 Antibody (OX-86) 是一种抗小鼠 OX40/CD134 IgG1 单克隆抗体。Anti-Mouse OX40/CD134 Antibody (OX-86) 可以增强 CD8+ T 细胞的抗肿瘤功能。Anti-Mouse OX40/CD134 Antibody (OX-86) 能够逆转免疫抑制，增强抗原呈递和 T 细胞激活。Anti-Mouse OX40/CD134 Antibody (OX-86) 可用于研究癌症如乳头状瘤和白血病。

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规格 价格 是否有货 数量
1 mg ￥630
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5 mg ￥2200
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10 mg ￥3500
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Anti-Mouse OX40/CD134 Antibody (OX-86) 相关抗体

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OX2 Receptor OX1 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse OX40/CD134 Antibody (OX-86) is an anti-mouse OX40/CD134 IgG1 monoclonal antibody. Anti-Mouse OX40/CD134 Antibody (OX-86) can enhance the anti-tumor function of CD8+ T cells. Anti-Mouse OX40/CD134 Antibody (OX-86) can reverse immune suppression, enhance antigen presentation and T cell activation. Anti-Mouse OX40/CD134 Antibody (OX-86) can be used for research on cancer such as papilloma and leukemia[1][2][3][4].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

OX40/CD134
体外研究
(In Vitro)

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg/mL，5-7 天) 上调 DCs 的活化标志物 (CD40 和 CD86)，并降低 SB28-OVA 和 EG7-OVA 细胞中 PD-L1 的表达[3]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 µg/mL，1 小时) 显著增强了肿瘤浸润淋巴细胞 (TIL) 诱导的肿瘤细胞凋亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse OX40/CD134 Antibody (OX-86) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg，腹腔注射，每周两次) 对携带 TC-1 肿瘤的雌性 C57BL/6 小鼠的肿瘤生长具有有限的抑制作用[1]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 mg/kg，腹腔注射，每周一次，2 剂) 与 PEG-MTAP 联合使用可显著抑制携带 L1210 肿瘤的 DBA/2 小鼠的肿瘤生长[2]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (200 µg，腹腔注射，在第 4、7 和 10 天) 显著抑制携带 SB28-OVA 或 EG7-OVA 肿瘤的雌性 C57BL/6 小鼠的肿瘤生长[3]。
Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg，腹腔注射，每周两次，持续 2 周) 可延缓携带 MC38 肿瘤的 C57BL/6 小鼠的肿瘤生长并增强 CD8+ T 细胞功能[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×105 TC-1 cells injected female C57BL/6 mice (6-8 weeks)[1]
Dosage: 100 µg
Administration: Intraperitoneal injection (i.p.), twice a week
Result: Had a weak inhibitory effect on tumor growth.
Animal Model: 5×104 L1210 cells injected DBA/2 mice (6-8 weeks)[2]
Dosage: 10 mg/kg, combined with PEG-MTAP (50 mg/kg, s.c., 3 times a week, for 5 dose)
Administration: Intraperitoneal injection (i.p.), once a week, for 2 dose
Result: Significantly inhibited tumor volume.
Animal Model: 1600 SB28-OVA cells or 25000 EG7-OVA cells injected female C57BL/6 mice (6-8 weeks)[3]
Dosage: 200 µg
Administration: Intraperitoneal injection (i.p.), on day 4, 7 and 10
Result: Extended the survival period of mice (median survival period extended from 26 days to 31 days).
Reduced the proportion of Tregs and increased the number of memory T cells.
Animal Model: C57BL/6 mice bearing MC38/gp100 tumors[4]
Dosage: 100 µg
Administration: Intraperitoneal injection (i.p.), twice a week, for 2 weeks
Result: Delayed tumor growth.
Enhanced CD8+ T cell function.
基因 ID

22163  [NCBI]

Accession
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized Mouse OX40 Protein, His Tag can bind Anti-Mouse OX40/CD134 Antibody (OX-86). The EC50 for this effect is 171 ng/mL.
纯度 & 产品资料
参考文献

Anti-Mouse OX40/CD134 Antibody (OX-86) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse OX40/CD134 Antibody (OX-86)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOX40/CD134TC-1L1210CD8T cellsSB28EG7MC38Inhibitorinhibitorinhibit

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