2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 

目录号: HY-P990156 纯度: 95.00%
COA 技术支持

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 是一种抗小鼠 Thy1.1/CD90.1 IgG2a 单克隆抗体。Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 可以耗竭 CD90.1+ 细胞。Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 可以清除 Tregs。Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 可用于研究炎症疾病和免疫反应，如气道炎症和实验性自身免疫性脑脊髓炎 (EAE)。

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Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) Chemical Structure

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Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1 IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1+ cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE)[1][2][3].

同型

Mouse IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

Thy1.1/CD90.1
体内研究
(In Vivo)

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (200 μg，腹腔注射，第 8 天单次剂量或从第 64 天或第 67 天开始每天一次) 在具有屋尘螨 (HDM) 诱导的过敏性气道炎症模型的 10BiT/Foxp3eGFP 小鼠中耗尽 CD90.1+ 细胞[1]。
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (250 μg，腹腔注射，单次剂量，注射 Tregs-IL2pa 后 133 天) 可以清除具有细胞移植模型的雄性 B6 Thy1.2 小鼠的 Tregs[2]。
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) (200 μg，腹腔注射，每隔一天一次，直到出现疾病症状) 在 MOG35-55 (HY-P1240) 诱导的实验性自身免疫性脑脊髓炎 (EAE) 模型的 C57BL/6 小鼠中耗尽 Thy1.1+ 树突状细胞 (DC)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10BiT/Foxp3eGFP mice (6-8 weeks) with HDM (20 μg) induced allergic airway inflammation model[1]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), single dose on day 8 for the acute model and once daily from day 64 or day 67 for the memory model
Result: Exacerbated inflammation and increased eosinophils in the acute model.
Did not affect inflammation or cytokine production in the memory model.
Animal Model: 9×105 Tregs-IL2pa male B6 Thy1.2 mice (12-20 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), single dose, 133 days after the injection of Tregs-IL2pa
Result: Could effectively clear Tregs-IL2pa marked with Thy1.1 and the removal effect was long-lasting.
Animal Model: MOG35-55 (200 μg) induced C57BL/6 mice[3]
Dosage: 200 µg
Administration: Intraperitoneal injection (i.p.), once every other day, until symptoms of the disease appear
Result: Significantly inhibited the development of EAE.
Significantly reduced EAE score.
基因 ID

21838  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)Transmembrane GlycoproteinThy1.1/CD90.1TregimmunologyEAEairway inflammationInhibitorinhibitorinhibit

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