2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse TIM-4 Antibody (RMT4-54)

Anti-Mouse TIM-4 Antibody (RMT4-54) 

目录号: HY-P990152
技术支持

Anti-Mouse TIM-4 Antibody (RMT4-54) 是一种源自大鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 TIM-4。Anti-Mouse TIM-4 Antibody (RMT4-54) 与小鼠 T 细胞免疫球蛋白及黏蛋白结构域 4 (TIM-4) 发生反应，并阻断 TIM-4 信号传导。Anti-Mouse TIM-4 Antibody (RMT4-54) 抑制凋亡细胞的吞噬作用。Anti-Mouse TIM-4 Antibody (RMT4-54) 可用于免疫学和代谢性疾病的研究。

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Anti-Mouse TIM-4 Antibody (RMT4-54)

Anti-Mouse TIM-4 Antibody (RMT4-54) Chemical Structure

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Anti-Mouse TIM-4 Antibody (RMT4-54) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease[1][2].

同型

Rat IgG2a kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

TIM-4
体外研究
(In Vitro)

Anti-Mouse TIM-4 Antibody (RMT4-54) (20 μg/mL, 30 mins) 可消除 Tim-4/NRK 细胞与凋亡细胞的结合[1]。
Anti-Mouse TIM-4 Antibody (RMT4-54) (20 μg/mL, 30 mins) 抑制腹膜常驻 Mac1+ 细胞对凋亡细胞的吞噬作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TIM-4 Antibody (RMT4-54) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse TIM-4 Antibody (RMT4-54) (200 μg/mouse，腹腔注射，每周两次，持续 4 周) 增加了 C57BL/6 小鼠中的 TUNEL+ 细胞[1]。
Anti-Mouse TIM-4 Antibody (RMT4-54) (200 μg，腹腔注射，在高脂饮食过夜前 72 小时及当天给药) 消除了高脂饮食喂养的模型小鼠中高密度脂蛋白的释放[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 200 μg/mouse
Administration: Intraperitoneally injection, twice a week for 4 weeks
Result: Significantly increased TUNEL+ cells.
Induced anti-dsDNA antibodies.
Animal Model: High-fat diet (HFD) feeding mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, 72 h and on the day prior to the overnight HFD
Result: Specifically abrogated the release of high-density lipoproteins.
Increased CD36 expression on F4/80highTim4+ATMs.
基因 ID

276891  [NCBI]

Accession

Q6U7R4 / NP_848874.3
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse TIM-4 Antibody (RMT4-54) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TIM-4 Antibody (RMT4-54)Transmembrane GlycoproteinTIM-4PhagocytosisHDLTUNEL+ cellsImmunologyInhibitorinhibitorinhibit

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