2. Immunology/Inflammation
  3. TROP2
  4. Anti-TROP-2 Antibody (Pr1E11)

Anti-TROP-2 Antibody (Pr1E11) 

目录号: HY-P990827 纯度: 95.00%
COA 技术支持

Anti-TROP-2 Antibody (Pr1E11) 是一种小鼠 IgG1 κ 嵌合抗体抑制剂，靶向人 TROP-2。Anti-TROP-2 Antibody (Pr1E11) 能以高亲和力特异性结合 TROP-2，且内化活性较低。Anti-TROP-2 Antibody (Pr1E11) 可用于癌症研究，如上皮癌和原发性胰腺癌。

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Anti-TROP-2 Antibody (Pr1E11)

Anti-TROP-2 Antibody (Pr1E11) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2200
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Anti-TROP-2 Antibody (Pr1E11) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-TROP-2 Antibody (Pr1E11) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human TROP-2. Anti-TROP-2 Antibody (Pr1E11) specifically binds to TROP-2 with high affinity and shows low internalization activitv. Anti-TROP-2 Antibody (Pr1E11) can be used for the research of cancer, such as epithelial cancer and primary pancreatic cancer[1].

同型

Mouse IgG1 kappa
反应种属

Human
IC50 & Target

TROP-2
体外研究
(In Vitro)

Anti-TROP-2 Antibody (Pr1E11) (去岩藻糖基化 [无岩藻糖] 嵌合型 Pr1E11) (0.1-1,000 ng/mL, 4 h) 在 BxPC3 和 Colo205 细胞中显示出抗体依赖性细胞毒性 (ADCC) 活性，但不显示补体依赖性细胞毒性 (CDC) 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-TROP-2 Antibody (Pr1E11) 相关抗体:
体内研究
(In Vivo)

Anti-TROP-2 Antibody (Pr1E11) (去岩藻糖基化 [无岩藻糖] 嵌合型 Pr1E11) (200 μg，腹腔注射，每周两次，持续 4 周) 在 BxPC3/Colo205 肿瘤 SCID 小鼠中显示出抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BxPC3/Colo205 tumor SCID mice[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, twice a week for 4 weeks
Result: Suppressed tumor growth.
Showed the minimum tumor growth inhibition ratio (T/Cmin) with 0.36 and 0.29, respectively.
基因 ID

56753  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-TROP-2 Antibody (Pr1E11) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-TROP-2 Antibody (Pr1E11)TROP2EGP-1M1S1GA733-1TROP-2TACSTD2BxPC3Colo205Inhibitorinhibitorinhibit

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目录号：
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