2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. ART5803

ART5803 是一种靶向 NMDAR 的人源化 IgG1 单克隆抗体抑制剂。ART5803 能够高亲和力地结合 NMDAR GluN1 亚基的 N 端结构域 (NTD) (GluN1-NTD)。ART5803 阻断致病性自身抗体诱导的 NMDAR 内化，并恢复细胞表面 NMDAR 的表达和功能。ART5803 逆转狨猴疾病模型中的行为异常和 NMDAR 的表达。ABT-147 可用于抗 NMDAR 脑炎研究。

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ART5803

ART5803 Chemical Structure

CAS No. : 3058434-76-4

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ART5803 相关抗体

Top Publications Citing Use of Products

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis[1].

反应种属

Human
IC50 & Target[1]

GluN1-NTD

 

靶点

NMDAR
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ART5803 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ART58033058434-76-4ART 5803ART-5803iGluRIonotropic glutamate receptorsNMDARMonoclonal antibodyGluN1-NTDNMDAR internalizationMarmoset disease modelsAnti-NMDAR encephalitisInhibitorinhibitorinhibit

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目录号：
HY-P991611
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