Artemisinin-¹³C,d₄  (Synonyms: 青蒿素-¹³C,d₄; Qinghaosu-¹³C,d₄; NSC 369397-13C,d₄)

Artemisinin-¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants^[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects^[2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) 浓度依赖性地抑制 Aβ25-35 诱导的 PC12 细胞毒性^[2]。
Artemisinin (1-100 μM; 24 hours) 以剂量依赖性方式选择性地抑制癌细胞生长，其对 UMRC-2 细胞和 CAKI-2 细胞的 IC50 值分别为23.97, 31.30 μM^[3]。
Artemisinin (25, 50 μM; 24 hours) 以剂量依赖性方式抑制 UMRC-2 和 CAKI-2 细胞中 AKT 的磷酸化^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Artemisinin (gavage; 20 mg/kg/day; for two weeks) 抑制 UMRC-2 异种移植肿瘤的生长^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

287.35

C₁₄¹³CH₁₈D₄O₅

青蒿素-¹³C,d₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.  [Content Brief]

  [3]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.  [Content Brief]