1. 辅酶及其他
  2. Asfotase alfa

Asfotase alfa  (Synonyms: ENB-0040)

目录号: HY-108786 纯度: 97.88%
COA

Asfotase alfa (ENB-0040) 是一种骨靶向的基因工程糖蛋白。Asfotase alfa 在 Akp2−/− 敲除小鼠中增加小鼠的生存率、骨矿化和骨长,防止足部、胸腔、下肢、颌骨的矿化缺陷。Asfotase alfa 可用于围产期、婴幼儿和青少年起病性低磷酸酶血症 (HPP) 的研究。

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Asfotase alfa Chemical Structure

Asfotase alfa Chemical Structure

CAS No. : 1174277-80-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2−/− knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP)[1].

种属

Human

体内研究
(In Vivo)

Asfotase alfa (0.5-8.2 mg/kg; s.c. once daily for 43 days) shows dose-response relationships that strongly support the pharmacological efficacy for HPP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Akp2−/− knockout mice[1]
Dosage: 0.5, 2.0 and 8.2 mg/kg
Administration: Subcutaneous injection; once daily for 43 days
Result: Dose-dependently increased the survival rate of mice, bone mineralization and prevention of mineralization defects of the feet, rib cage, lower limbs, jaw bones, the median survival, body weight, and bone length. Showed a clear relationship between daily dose and achieving a healthy BW and the ED80 (the dose that prevents bone defects in 80% of mice) was 3.2, 2.8 and 2.9 mg/kg/day for these sites. Remained increasing urinary PPi concentrations in all treatment groups.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 97.88%

参考文献

Asfotase alfa 相关分类

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Asfotase alfa
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HY-108786
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