2. Immunology/Inflammation Apoptosis NF-κB
  3. Interleukin Related MDM-2/p53 NF-κB
  4. Astegolimab

Astegolimab  (Synonyms: 艾特利单抗; MSTT 1041A; RG 6149)

目录号: HY-P99444 纯度: 99.00%
COA 技术支持

Astegolimab (MSTT 1041A; RG 6149) 是一种人 IgG2 单克隆抗体，可通过靶向 IL-33 受体 ST2 来阻断 IL-33 信号传导。Astegolimab 可降低 p53 表达，并减轻 IL33 导致的 SASP 因子 (例如 IL1α、IL6 和MCP1) 上调。Astegolimab 可减轻 IL33 导致的 p-p65/p65 比率升高。Astegolimab 可阻断 CM 诱导的中性粒细胞胞外陷阱 (NET) 形成。Astegolimab 可用于慢性阻塞性肺疾病 (COPD) 和心肌研究。

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CAS No. : 2173054-79-8

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1 mg ￥3000
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5 mg ￥7900
In-stock
10 mg ￥10596
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25 mg ￥15480
In-stock
50 mg ￥21120
In-stock
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Astegolimab 相关抗体

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research[1][2][3].

同型

Human IgG2 kappa
推荐同型对照抗体
IC50 & Target[1]

ST2

 

体外研究
(In Vitro)

Astegolimab 可以阻断 HL-60 细胞中 CM 诱导的中性粒细胞胞外陷阱 (NET) 形成效应[2]。
Astegolimab (10 μM) 可阻断外源性 IL33 对心肌细胞 (AC16) 衰老的影响[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Astegolimab 相关抗体:

Western Blot Analysis[3]

Cell Line: AC16 cells treated with IL33
Concentration: 10 μM
Incubation Time:
Result: Reduced p53 expression.
Mitigated IL33-upregulated SASP factors such as IL1α, IL6 and MCP1.
Mitigated IL33-increased p-p65/p65 ratio.
Clinical Trial
基因 ID

9173  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

144.98 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾特利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized ST2/IL1RL1 Protein, Human can bind Astegolimab. The EC50 for this effect is 28.29 ng/mL.
  • Loaded ST2/IL1RL1 Protein, Human (310a.a, HEK293, His, HY-P70615) on AHC2 biosensor, can bind Astegolimab with an affinity constant of 2.022E-10 M as determined in BLI assay.
纯度 & 产品资料

纯度: 99.00%

COA (266 KB) SDS-PAGE (110 KB) SEC-HPLC (465 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Astegolimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astegolimab2173054-79-8MSTT 1041A RG 6149艾特利单抗RG6149RG 6149RG-6149Interleukin RelatedMDM-2/p53NF-κBILNuclear factor-κBNuclear factor-kappaBIgG2monoclonal antibodyIL-33ST2chronic obstructive pulmonary diseaseCOPDInhibitorinhibitorinhibit

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