1. Metabolic Enzyme/Protease Autophagy
  2. HMG-CoA Reductase (HMGCR) Autophagy
  3. Atorvastatin-d5 hemicalcium

Atorvastatin-d5 hemicalcium  (Synonyms: 阿托伐他汀 d5 (1/2钙盐))

目录号: HY-B0589S 纯度: ≥98.0%
COA 产品使用指南

Atorvastatin-d5 (hemicalcium) 是 Atorvastatin 的氘代物。Atorvastatin hemicalcium 是一种具有口服活性的 HMG-CoA 还原酶抑制剂,具有有效降低血脂的能力。Atorvastatin hemicalcium 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。

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Atorvastatin-d<sub>5</sub> hemicalcium Chemical Structure

Atorvastatin-d5 hemicalcium Chemical Structure

CAS No. : 222412-82-0

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atorvastatin-d5 (hemicalcium) is the deuterium labeled Atorvastatin. Atorvastatin hemicalcium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

583.71

Formula

C33H30D5FN2O5.1/2Ca

CAS 号
性状

固体

颜色

White to off-white

中文名称

阿托伐他汀 d5 (1/2钙盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

参考文献

Atorvastatin-d5 hemicalcium 相关分类

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Atorvastatin-d5 hemicalcium
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HY-B0589S
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