2. Metabolic Enzyme/Protease Autophagy
  3. HMG-CoA Reductase (HMGCR) Autophagy
  4. Atorvastatin hemicalcium trihydrate

Atorvastatin hemicalcium trihydrate  (Synonyms: 阿托伐他汀半钙三水合物；阿托他伐汀半钙三水合物)

目录号: HY-B0589E
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Atorvastatin hemicalcium trihydrate 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。Atorvastatin hemicalcium trihydrate 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。

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Atorvastatin hemicalcium trihydrate Chemical Structure

Atorvastatin hemicalcium trihydrate Chemical Structure

CAS No. : 344920-08-7

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Atorvastatin hemicalcium trihydrate 的其他形式现货产品:

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Atorvastatin hemicalcium trihydrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 28 篇科研文献

IF
Proliferation Assay

    Atorvastatin hemicalcium trihydrate purchased from MCE. Usage Cited in: Oncogene. 2022 Oct 31.  [Abstract]

    ATP assay. The combination of Atorvastatin (2.5, 5, 10, 20 μM; 48 h) and SR1078 synergistically inhibits CRC cell viability.

    Atorvastatin hemicalcium trihydrate purchased from MCE. Usage Cited in: Endocrinology. 2018 May 1;159(5):2008-2021.  [Abstract]

    Male C57BL/6 mice are intragastrically treated with Atorvastatin (0.1 mg/kg/day) and placebo for 10 weeks in the presence of HFD after 10-week-HFD feeding and then sacrificed for sample collection. H&E and oil red O staining of frozen liver sections.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Atorvastatin hemicalcium trihydrate is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium trihydrate inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

    体外研究
    (In Vitro)

    Atorvastatin hemicalcium trihydrate treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Atorvastatin hemicalcium trihydrate 相关抗体:
    体内研究
    (In Vivo)

    Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) hemicalcium trihydrate treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Forty 8-week-old ApoE−/− mice induced with angiotensin II (Ang II)[5]
    Dosage: 20 mg/kg, 30 mg/kg
    Administration: Oral gavage; once a day; for 28 days
    Result: Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.
    Clinical Trial
    分子量

    632.73

    Formula

    C33H35FN2O5.1/2Ca.3H2O
    CAS 号
    中文名称

    阿托伐他汀半钙三水合物；阿托他伐汀半钙三水合物
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Atorvastatin hemicalcium trihydrate 相关分类

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    Keywords:

    Atorvastatin hemicalcium344920-08-7阿托伐他汀半钙三水合物阿托他伐汀半钙三水合物HMG-CoA Reductase (HMGCR)AutophagyInhibitorinhibitorinhibit

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