2. Anti-infection
  3. SARS-CoV
  4. Obeldesivir

Obeldesivir  (Synonyms: ATV006)

目录号: HY-145994 纯度: 99.41%
COA 产品使用指南

摩尔计算器

Obeldesivir (ATV006) 是一种口服有效的抗病毒剂和 GS-441524 酯类前体。 Obeldesivir 能有效抑制 SARS-CoV-2 及其变体的复制。Obeldesivir 可用于SARS-CoV-2 研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Obeldesivir Chemical Structure

Obeldesivir Chemical Structure

CAS No. : 2647441-36-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥3000
In-stock
10 mg ￥4800
In-stock
25 mg ￥9500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Obeldesivir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research[1].

体外研究
(In Vitro)

Obeldesivir (0.001-100 μM; 48 h; Vero E6 cells) inhibits the replication of authentic SARS-CoV-2 and its variants of concern. Obeldesivir has an overall >4-fold and >12-fold potency improvement in inhibiting the replication of Delta and Omicron variants, with EC50 values of 0.349 μM and 0.106 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Obeldesivir 相关抗体:
体内研究
(In Vivo)

Obeldesivir (5-25 mg/kg; p.o. and i.v.; Sprague Dawley rats) has favorable pharmacokinetic profiles in rats with high oral bioavailability (F %) of 81.5% and maximum blood concentration (Cmax) of 8.2 μM[1].
Obeldesivir (250-500 mg/kg; p.o.; daily, for 4 days; hACE2 knock-in and Ad5-hACE2 mice) has antiviral activity and inhibits SARS-CoV-2 replication in mouse models[1].
Obeldesivir (100-250 mg/kg; p.o.; daily, for 10 days) reduces lung damage and protects K18-hACE2 mice[1].
Obeldesivir (10-150 mg/kg; p.o.; daily, for 3 days) reduces virus titers and lung damage caused by Delta variant infection in K18-hACE2 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[1]
Dosage: 5 and 25 mg/kg
Administration: Oral administration (25 mg/kg) and intravenous injection (5 mg/kg)
Result: 1.19
parameters i.v. (5 mg/kg) p.o. (25 mg/kg)
AUClast (μM·h) 5.6 22.8
T1/2 (h) 1.5 1.2
Tmax (h) 0.5
Cmax (μM) 8.7 8.2
F % 81.5
Animal Model: hACE2 knock-in and Ad5-hACE2 mice[1]
Dosage: 250 and 500 mg/kg
Administration: Oral administration; daily, for 4 days
Result: Inhibited gRNA and sgRNA, which is Biomarkers of coronavirus replication. Reduced the viral load and pathological damage of the lung.
Animal Model: K18-hACE2 mice[1]
Dosage: 100 and 250 mg/kg
Administration: Oral administration; daily, for 10 days
Result: Reduced viral RNA and increased the survival rate of mice. Reduced evidence of lung pathology and the production of inflammatory cytokines and chemokines in the lung tissues.
Animal Model: K18-hACE2 mice[1]
Dosage: 10, 30, 80 and 150 mg/kg
Administration: Oral administration; daily, for 3 days
Result: Reduced viral load in a dose-dependent manner and alleviated the symptoms in the lung.
Clinical Trial
分子量

361.35

Formula

C16H19N5O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (691.85 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7674 mL 13.8370 mL 27.6740 mL
5 mM 0.5535 mL 2.7674 mL 5.5348 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Obeldesivir 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7674 mL 13.8370 mL 27.6740 mL 69.1850 mL
5 mM 0.5535 mL 2.7674 mL 5.5348 mL 13.8370 mL
10 mM 0.2767 mL 1.3837 mL 2.7674 mL 6.9185 mL
15 mM 0.1845 mL 0.9225 mL 1.8449 mL 4.6123 mL
20 mM 0.1384 mL 0.6918 mL 1.3837 mL 3.4592 mL
25 mM 0.1107 mL 0.5535 mL 1.1070 mL 2.7674 mL
30 mM 0.0922 mL 0.4612 mL 0.9225 mL 2.3062 mL
40 mM 0.0692 mL 0.3459 mL 0.6918 mL 1.7296 mL
50 mM 0.0553 mL 0.2767 mL 0.5535 mL 1.3837 mL
60 mM 0.0461 mL 0.2306 mL 0.4612 mL 1.1531 mL
80 mM 0.0346 mL 0.1730 mL 0.3459 mL 0.8648 mL
100 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.6918 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Obeldesivir2647441-36-7ATV006ATV 006ATV-006SARS-CoVSARS coronaviruspodrugsantiviralSARS-CoV-2Vero E6 cellsviral loadRNAInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Obeldesivir
目录号：
HY-145994
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z