1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. Src
    Bcr-Abl
    Apoptosis
  3. AZD0424

AZD0424 

目录号: HY-112314
产品使用指南

AZD0424 是选择性 Src/Abl 激酶抑制剂,可口服,具有抗肿瘤活性。AZD0424 可以诱导淋巴瘤细胞凋亡 (apoptosis) 和细胞周期停滞。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

AZD0424 Chemical Structure

AZD0424 Chemical Structure

CAS No. : 692054-06-1

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2].

IC50 & Target

Src/Abl kinase inhibitor (SrcK-I), apoptosis[1]

In Vitro

AZD0424 (1-5 μM; 24-48 hours) is emerged to be the more effective of the three tested inhibitors (AZM559756, AZD0530 and AZD0424), inducing the highest levels of apoptosis with the lowest concentrations in lymphoma cells[2].
AZD0424 (5 μM; 48 hours) leads to increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells, whereas the cell cycle progression of the nonsensitive cell lines Raji and Jurkat remains unaffected[2].

Apoptosis Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji, Jurkat, Karpas-299 and HUT78 cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 24 hours, 48 hours
Result: Induced apoptosis in lymphoma cells.

Cell Cycle Analysis[2]

Cell Line: DOHH-2, WSU-NHL, Raji and Jurkat cells
Concentration: 1 μM; 2 μM; 3 μM; 4 μM; 5 μM;
Incubation Time: 48 hours
Result: Increased G0/G1 cell cycle arrest in DOHH-2 and WSU-NHL cells.
Molecular Weight

528.99

Formula

C₂₅H₂₉ClN₆O₅

CAS No.

692054-06-1

SMILES

CC(N1CCN(CCOC2=CC3=NC=NC(NC4=C(OCO5)C5=NC=C4Cl)=C3C(OC(C)C)=C2)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
AZD0424
目录号:
HY-112314
需求量:

AZD0424

Cat. No.: HY-112314