2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE)
  4. BChE/MAO-B-IN-2

BChE/MAO-B-IN-2 是一种具有良好血脑屏障通透性的 BChE (IC50 = 0.05 μM, Ki = 0.01 μM) 和 MAO-B 的双重抑制剂 (IC50 = 0.45 μM，Ki = 0.08 μM)。 BChE/MAO-B-IN-2具有抗氧化活性，包括 DPPH 自由基清除、CUPRAC 铜离子还原和超氧阴离子清除。BChE/MAO-B-IN-2 可用于阿尔茨海默病 (AD) 研究。

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BChE/MAO-B-IN-2

BChE/MAO-B-IN-2 Chemical Structure

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BChE/MAO-B-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BChE/MAO-B-IN-2 is a dual inhibitor of BChE (IC50 = 0.05 μM, Ki = 0.01 μM) and MAO-B (IC50 = 0.45 μM, Ki = 0.08 μM) with good blood-brain barrier permeability. BChE/MAO-B-IN-2 exhibits antioxidant activity, including DPPH radical scavenging, CUPRAC copper ion reduction, and superoxide anion scavenging. BChE/MAO-B-IN-2 can be used for the study of Alzheimer's disease (AD)[1].

IC50 & Target[1]

MAO-B

0.45 μM (IC50)

MAO-B

0.08 μM (Ki)

hBCHE

0.05 μM (IC50)

hBCHE

0.01 μM (IC50)

MAO-A

5.00 μM (IC50)

MAO-A

1.20 μM (Ki)

AChE

0.8 μM (Ki)

AChE

2 μM (EC50)

体外研究
(In Vitro)

BChE/MAO-B-IN-2 (Compound 4a-S) 显示出 DPPH 自由基清除活性 (IC50 = 3.57 mM)，在 CUPRAC 实验中具有抗氧化活性 (IC50 = 33 μM) 以及超氧阴离子清除能力 (IC50 = 24 μM)[1]。
MAO-B-IN-48 (1-25 μM) 对 HepG2 细胞无细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BChE/MAO-B-IN-2 相关抗体:
体内研究
(In Vivo)

BChE/MAO-B-IN-2 (20 mg/kg，灌胃给药，一周) 可改善由 AlCl3 引起的小鼠认知障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 40mg/kg of AlCl3 was administered intraperitoneally (i.p.) to male Balb/c mice for 30 days[1]
Dosage: 20 mg/kg
Administration: i.g. for 1 week
Result: Ameliorated the cognitive impairment induced by AlCl3 in mice.
分子量

286.37

Formula

C17H22N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BChE/MAO-B-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE/MAO-B-IN-2Monoamine OxidaseCholinesterase (ChE)MAOAlzheimer's diseaseMAO-BBChEβ-amyloid peptidesInhibitorinhibitorinhibit

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