2. MAPK/ERK Pathway
  3. Raf
  4. Belvarafenib TFA

Belvarafenib TFA  (Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA)

目录号: HY-109080A
COA 产品使用指南

摩尔计算器

Belvarafenib TFA (HM95573 TFA) 是一种有效的，广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。

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Belvarafenib TFA Chemical Structure

Belvarafenib TFA Chemical Structure

CAS No. : 2443966-84-3

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Belvarafenib TFA 的其他形式现货产品:

Customer Review

Other Forms of Belvarafenib TFA:

Belvarafenib TFA 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Raf 亚型特异性产品:

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BRaf c-Raf Raf

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].

IC50 & Target

IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].
体外研究
(In Vitro)

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Belvarafenib TFA 相关抗体:
Clinical Trial
分子量

592.95

Formula

C25H17ClF4N6O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Belvarafenib TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belvarafenib2443966-84-3HM95573GDC-5573RG6185HM 95573HM-95573GDC5573GDC 5573RG 6185RG-6185RafRaf kinasesInhibitorinhibitorinhibit

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目录号：
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