2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP DNA/RNA Synthesis Apoptosis
  4. BER-IN-1

BER-IN-1 是一种碱基切除修复 (BER) 抑制剂，以 DNA 脱碱基位点为靶点。BER-IN-1 通过 β-消除和 β,δ-消除切割脱碱基位点，破坏碱基切除修复 (BER) 通路并导致 DNA 双链断裂 (DSBs)。BER-IN-1 能够增强 PARP 抑制剂 Olaparib (HY-10162) 在同源重组修复 (HR) 正常的癌细胞 (MDA-MB-231、HeLa 和 SKOV3) 中的作用。BER-IN-1 与 Olaparib 联合使用时，可诱导 S 期阻滞和细胞凋亡 (apoptosis)。BER-IN-1 可用于癌症的研究，如乳腺癌、宫颈癌和卵巢癌。

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BER-IN-1

BER-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

BER-IN-1 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib. BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer[1].

IC50 & Target[1]

PARP-1

 

体外研究
(In Vitro)

BER-IN-1 (Compound BA-6) 对 MDA-MB-231 细胞的 IC50 值为 10.92 μM，对 HeLa 细胞为 6.37 μM，对 SKOV3 细胞为 7.76 μM，对 OVCAR3BRCA1−/− 细胞为 5.53 μM[1]。
BER-IN-1 (0.7-50 μM, 24-72 h) 与 Olaparib (HY-10162) 联合使用时，可显著降低 MDA-MB-231、HeLa 和 OVCAR3BRCA1−/− 细胞的存活率[1]。
BER-IN-1 (5-10 μM) 与 Olaparib 联合使用时，可抑制 MDA-MB-231 和 HeLa 癌细胞的集落形成[1]。
BER-IN-1 (5-50 μM) 与 Olaparib 联合使用时，会增加 MDA-MB-231 和 HeLa 癌细胞中显著的 β-消除产物并诱导 DNA 双链断裂[1]。
BER-IN-1 (5-10 μM, 24 h) 与 Olaparib 联合使用时，可诱导 MDA-MB-231 和 HeLa 癌细胞的 S 期阻滞和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BER-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells
Concentration: 0.7, 1.5, 3.1, 6.2, 12.5, 25 and 50 μM
Incubation Time: 24 or 72 h, companied with Olaparib (0.15-200 μM)
Result: Significantly reduced cell viability.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 and HeLa cancer cells
Concentration: 5 and 10 μM
Incubation Time: 24 h, companied with Olaparib (5-10 μM)
Result: Increased cells in the G2/M phase and S-phase arrest.
分子量

243.31

Formula

C13H17N5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BER-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BER-IN-1PARPDNA/RNA SynthesisApoptosispoly ADP ribose polymerase BEROlaparibDNAMDA-MB-231HeLaSKOV3Breast cancerCervical cancerOvarian cancerInhibitorinhibitorinhibit

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HY-175466
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