2. Apoptosis
  3. Bcl-2 Family
  4. BM-1197

BM-1197  (Synonyms: UBX1967)

目录号: HY-120882 纯度: 99.43%
COA 产品使用指南

摩尔计算器

BM-1197 (UBX1967) 是一种有效的和选择性的 Bcl-2/Bcl-xL 的双重抑制剂，抑制 Bcl-2 和 Bcl-xL 的 IC50 值分别为 3.5 nM 和 5.2 nM。BM-1197 在体外和体内均表现出抗肿瘤作用。

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BM-1197 Chemical Structure

BM-1197 Chemical Structure

CAS No. : 1391107-89-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥83412
In-stock
1 mg ￥6700
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

BM-1197 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BM-1197 (UBX1967) is a potent and selective inhibitor of dual Bcl-2/Bcl-xL, with IC50s of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo[1][2].

IC50 & Target[1]

Bcl-2

3.5 nM (IC50)

Bcl-xL

5.2 nM (IC50)

体外研究
(In Vitro)

BM-1197 (2-2000 nM; 3 d) has marginal cytotoxicity against wild-type mouse embryonic fibroblast (MEF) cells but exerts potent growth-inhibitory activity in the MCL1−/− cells[1].
BM-1197 shows potent growth-inhibitory activities in 7 small cell lung cancer (SCLC) cell lines with IC50s <100 nM, moderate activity in 3 SCLC cell lines with IC50s of ∼600 nM and weak activity in 2 SCLC cell lines with IC50s >2000 nM[1].
BM-1197 (100 nM; 16 h) potently induces apoptosis in H146 cells[1].
BM-1197 (100 nM; 2 h) disrupts the association between Bcl-xl and Puma or Bim in H146 cells[1].
BM-1197 (100 nM; 0.5-2 h) induces Bax translocation, and it (3-30 nM; 2 h) induces cytochrome c release in H146 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BM-1197 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MEF/MCL1−/− cells
Concentration: 2, 20, 200, 2000 nM
Incubation Time: 3 days
Result: Inhibited MCL1−/− cells proliferation.

Apoptosis Analysis[1]

Cell Line: H146 cells
Concentration: 100 nM
Incubation Time: 16 hours
Result: Induced apoptosis in a strictly Bax/Bak-dependent manner.

Western Blot Analysis[1]

Cell Line: H146 cells
Concentration: 100 nM
Incubation Time: 2 hours
Result: Attenuated the associations between Bcl-xL and BimEL or Puma.
体内研究
(In Vivo)

BM-1197 (10 mg/kg; i.v. daily 5 days per week for 2 weeks) results in rapid and complete tumor regression in all 8 mice in H146 and H1963 tumor model[1].
BM-1197 (15 mg/kg; i.v.) causes thrombocytopenia in mice but the effect is reversible even at highly efficacious doses[1].
BM-1197 (10 mg/kg; i.v. qd) exerts a strong anti-tumor effect and is well tolerated in OCI-Ly8 xenograft models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice bearing H146 cells[1]
Dosage: 10 mg/kg
Administration: I.v. daily 5 days per week for 2 weeks
Result: Remained tumor free for at least 32 days after the end of the treatment.
分子量

1131.78

Formula

C53H59ClF4N6O7S4
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (220.89 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8836 mL 4.4178 mL 8.8356 mL
5 mM 0.1767 mL 0.8836 mL 1.7671 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.43%

COA (175 KB) HNMR (370 KB) LCMS (300 KB)

产品使用指南 (1538 KB)
参考文献

BM-1197 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8836 mL 4.4178 mL 8.8356 mL 22.0891 mL
5 mM 0.1767 mL 0.8836 mL 1.7671 mL 4.4178 mL
10 mM 0.0884 mL 0.4418 mL 0.8836 mL 2.2089 mL
15 mM 0.0589 mL 0.2945 mL 0.5890 mL 1.4726 mL
20 mM 0.0442 mL 0.2209 mL 0.4418 mL 1.1045 mL
25 mM 0.0353 mL 0.1767 mL 0.3534 mL 0.8836 mL
30 mM 0.0295 mL 0.1473 mL 0.2945 mL 0.7363 mL
40 mM 0.0221 mL 0.1104 mL 0.2209 mL 0.5522 mL
50 mM 0.0177 mL 0.0884 mL 0.1767 mL 0.4418 mL
60 mM 0.0147 mL 0.0736 mL 0.1473 mL 0.3682 mL
80 mM 0.0110 mL 0.0552 mL 0.1104 mL 0.2761 mL
100 mM 0.0088 mL 0.0442 mL 0.0884 mL 0.2209 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BM-11971391107-89-3UBX1967BM1197BM 1197UBX 1967UBX-1967Bcl-2 FamilydualBcl-2Bcl-xLantitumorcancerInhibitorinhibitorinhibit

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