2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Carbonic Anhydrase CDK
  4. Carbonic anhydrase inhibitor 14

Carbonic anhydrase inhibitor 14 

目录号: HY-150570
产品使用指南

摩尔计算器

Carbonic anhydrase inhibitor 14 (Compound 8b) 是一种碳酸酐酶 (carbonic anhydrase) 抑制剂，其对 hCA I、hCA II、hCA IX 和 hCA XII 的 Ki 分别为 1203、99.7、9.4 和 27.7 nM。Carbonic anhydrase inhibitor 14 也能抑制 CDK2，其 IC50 为 20.3 μM。Carbonic anhydrase inhibitor 14 具有抗肿瘤活性。

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Carbonic anhydrase inhibitor 14 Chemical Structure

Carbonic anhydrase inhibitor 14 Chemical Structure

CAS No. : 2410402-75-2

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Carbonic anhydrase inhibitor 14 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].

IC50 & Target

CDK2

20.3 μM (IC50)

hCA XII

27.7 nM (Ki)

hCA IX

9.4 nM (Ki)

hCA II

99.7 nM (Ki)

hCA I

1203 nM (Ki)

分子量

395.44

Formula

C18H17N7O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carbonic anhydrase inhibitor 14 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbonic anhydrase inhibitor 142410402-75-2Carbonic anhydrase inhibitor14Carbonic anhydrase inhibitor-14Carbonic AnhydraseCDKCarbonate dehydrataseCyclin dependent kinaseantitumorMCF7Inhibitorinhibitorinhibit

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